Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3535002..3535620 Replicon chromosome
Accession NZ_CP103704
Organism Escherichia coli strain ST361

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T41_RS17160 Protein ID WP_001291435.1
Coordinates 3535402..3535620 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T41_RS17155 Protein ID WP_000344800.1
Coordinates 3535002..3535376 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T41_RS17145 (3530091) 3530091..3531284 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T41_RS17150 (3531307) 3531307..3534456 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5T41_RS17155 (3535002) 3535002..3535376 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T41_RS17160 (3535402) 3535402..3535620 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T41_RS17165 (3535792) 3535792..3536343 + 552 WP_000102564.1 maltose O-acetyltransferase -
M5T41_RS17170 (3536459) 3536459..3536929 + 471 WP_000136192.1 YlaC family protein -
M5T41_RS17175 (3537093) 3537093..3538643 + 1551 WP_064221513.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T41_RS17180 (3538685) 3538685..3539038 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5T41_RS17190 (3539417) 3539417..3539728 + 312 WP_000409911.1 MGMT family protein -
M5T41_RS17195 (3539759) 3539759..3540331 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T256262 WP_001291435.1 NZ_CP103704:3535402-3535620 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT256262 WP_000344800.1 NZ_CP103704:3535002-3535376 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References