Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2409824..2410462 Replicon chromosome
Accession NZ_CP103704
Organism Escherichia coli strain ST361

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag M5T41_RS11635 Protein ID WP_000813794.1
Coordinates 2410286..2410462 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5T41_RS11630 Protein ID WP_001270286.1
Coordinates 2409824..2410240 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T41_RS11610 (2404976) 2404976..2405917 - 942 WP_001251313.1 ABC transporter permease -
M5T41_RS11615 (2405918) 2405918..2406931 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
M5T41_RS11620 (2406949) 2406949..2408094 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M5T41_RS11625 (2408339) 2408339..2409745 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M5T41_RS11630 (2409824) 2409824..2410240 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5T41_RS11635 (2410286) 2410286..2410462 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5T41_RS11640 (2410684) 2410684..2410914 + 231 WP_000494244.1 YncJ family protein -
M5T41_RS11645 (2411006) 2411006..2412967 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5T41_RS11650 (2413040) 2413040..2413576 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M5T41_RS11655 (2413668) 2413668..2414843 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T256260 WP_000813794.1 NZ_CP103704:c2410462-2410286 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT256260 WP_001270286.1 NZ_CP103704:c2410240-2409824 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References