Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2353904..2355492 Replicon chromosome
Accession NC_015968
Organism Enterobacter asburiae LF7a

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ENTAS_RS11025 Protein ID WP_014070315.1
Coordinates 2354173..2355492 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ENTAS_RS11020 Protein ID WP_014070314.1
Coordinates 2353904..2354173 (+) Length 90 a.a.

Genomic Context

ENTAS_RS11000ENTAS_RS11010ENTAS_RS11015ENTAS_RS11020ENTAS_RS11025ENTAS_RS11030ENTAS_RS11035ENTAS_RS10990ENTAS_RS10995ENTAS_RS11005ENTAS_RS11040ENTAS_RS11045ENTAS_RS11050
Location: 2350632..2351405 (774 bp)
Type: Others
Protein ID: WP_014070310.1
Location: 2351967..2352320 (354 bp)
Type: Others
Protein ID: WP_014070312.1
Location: 2352462..2353754 (1293 bp)
Type: Others
Protein ID: WP_014070313.1
Location: 2353904..2354173 (270 bp)
Type: Antitoxin
Protein ID: WP_014070314.1
Location: 2354173..2355492 (1320 bp)
Type: Toxin
Protein ID: WP_014070315.1
Location: 2355943..2356230 (288 bp)
Type: Others
Protein ID: WP_014070316.1
Location: 2356237..2357529 (1293 bp)
Type: Others
Protein ID: WP_014070317.1
Location: 2349119..2349877 (759 bp)
Type: Others
Protein ID: WP_014070308.1
Location: 2349960..2350544 (585 bp)
Type: Others
Protein ID: WP_014070309.1
Location: 2351377..2351868 (492 bp)
Type: Others
Protein ID: WP_176408561.1
Location: 2357609..2358370 (762 bp)
Type: Others
Protein ID: WP_014070318.1
Location: 2358504..2359193 (690 bp)
Type: Others
Protein ID: WP_014070319.1
Location: 2359274..2359855 (582 bp)
Type: Others
Protein ID: WP_041162230.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ENTAS_RS109902349119..2349877-759WP_014070308.1trans-aconitate 2-methyltransferase-
ENTAS_RS109952349960..2350544-585WP_014070309.1nucleoside diphosphate pyrophosphatase-
ENTAS_RS110002350632..2351405+774WP_014070310.1DeoR/GlpR family DNA-binding transcription regulator-
ENTAS_RS110052351377..2351868-492WP_176408561.1ATP-binding protein-
ENTAS_RS110102351967..2352320+354WP_014070312.1hypothetical protein-
ENTAS_RS110152352462..2353754+1293WP_014070313.1glycoside hydrolase-
ENTAS_RS110202353904..2354173+270WP_014070314.1type II toxin-antitoxin system antitoxin HipBAntitoxin
ENTAS_RS110252354173..2355492+1320WP_014070315.1type II toxin-antitoxin system HipA family toxinToxin
ENTAS_RS110302355943..2356230+288WP_014070316.1VF530 family protein-
ENTAS_RS110352356237..2357529+1293WP_014070317.1glycoside hydrolase family 10 protein-
ENTAS_RS110402357609..2358370-762WP_014070318.1thiol:disulfide interchange protein DsbG-
ENTAS_RS110452358504..2359193-690WP_014070319.1VIT family protein-
ENTAS_RS110502359274..2359855-582WP_041162230.1cytochrome b/b6 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49030.13 Da        Isoelectric Point: 7.1625

>T25626 WP_014070315.1 NC_015968:2354173-2355492 [Enterobacter soli]
MPKLVTWMNNERVGELTKLTNGAHTFKYANEWLLNRYARPLSLSLPLQYGEITSDAVFNFFDNLLPDSPAVRDRIVKRYH
ARSRQPFDLLAEVGRDSVGAVTLLPANENSTTPEMMWETLSEEKLEKVLTAYQSDIPLGMINEENDFRISVAGAQEKTAL
LKAGDDWCIPKGITPTTHIIKLPIGEIKQPNATLDLSDSVDNEYFCLQLARALGIDVPNAEIIRAGRVRALAVERFDRRW
NASRSVLLRLPQEDMCQTFGLPSSVKYESDGGPGIPHIMAFLLGSSEALTDRYNFMKFQLFQWITGATDGHAKNFSIFIQ
PGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMSLNASKGRKNDIDKIYPRHFMATARAVRFPENQMTEIMQEFISDVP
QALDAVMKSLPTDFSQKVATSISRNVLRLHGRLSKSAGG

Download         Length: 1320 bp

>T25626 NC_015968:2354173-2355492 [Enterobacter soli]
ATGCCAAAATTAGTGACGTGGATGAATAACGAACGGGTCGGCGAACTGACAAAACTGACCAATGGGGCACATACGTTTAA
ATACGCCAATGAATGGCTACTTAACCGGTATGCCCGGCCATTGTCGTTATCGCTTCCGCTACAATATGGCGAAATTACCT
CCGATGCGGTGTTCAATTTCTTCGACAACCTGCTCCCGGATAGCCCGGCGGTCAGGGATCGTATTGTTAAGCGCTACCAT
GCCCGTTCCAGGCAACCCTTTGATTTACTGGCAGAGGTAGGGCGTGACAGCGTCGGCGCGGTGACGTTATTACCCGCTAA
TGAAAACAGCACGACACCGGAAATGATGTGGGAGACTCTGAGCGAAGAGAAACTCGAGAAGGTGTTGACGGCTTATCAGT
CAGACATCCCACTGGGGATGATTAATGAGGAAAATGATTTCCGCATTTCCGTTGCTGGCGCTCAGGAAAAAACAGCGCTC
CTTAAAGCCGGTGACGACTGGTGTATTCCGAAAGGTATCACGCCCACCACCCATATCATCAAGCTGCCGATTGGCGAGAT
AAAACAGCCCAATGCCACGCTGGATTTGAGCGATAGTGTGGATAATGAATACTTCTGTTTGCAGCTGGCCAGAGCGCTGG
GAATTGACGTGCCGAATGCGGAAATCATCAGAGCGGGCAGGGTGCGGGCACTTGCCGTCGAGCGTTTTGACCGCCGATGG
AACGCAAGCCGATCTGTTTTATTGCGCTTACCGCAGGAAGATATGTGCCAGACTTTTGGGCTTCCTTCGTCCGTGAAGTA
TGAGTCTGATGGCGGCCCCGGTATTCCACATATCATGGCATTTTTACTGGGTTCCAGCGAAGCGCTTACCGATCGTTATA
ATTTCATGAAATTCCAGCTATTTCAGTGGATAACAGGCGCAACCGATGGACATGCCAAGAACTTCTCAATATTCATCCAG
CCTGGCGGAAGCTATCGACTGACCCCGTTCTACGACATCATTTCGGCGTTTCCTGTGCTGGGCGGCGCCGGGATCCACAT
CAGCGATCTGAAACTGGCCATGAGCCTGAATGCCTCAAAAGGCCGTAAAAACGATATCGACAAGATCTATCCGAGACATT
TTATGGCAACAGCCAGGGCCGTCAGGTTTCCTGAAAACCAGATGACCGAGATTATGCAGGAATTTATCAGCGATGTGCCG
CAGGCACTGGATGCAGTGATGAAGTCTTTACCCACGGACTTTTCGCAAAAAGTCGCGACCTCGATATCCAGGAATGTGCT
CAGGCTGCATGGCCGACTGAGCAAAAGTGCAGGGGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10109.47 Da        Isoelectric Point: 8.5467

>AT25626 WP_014070314.1 NC_015968:2353904-2354173 [Enterobacter soli]
MKPPMIYSPVQLANTMRLVRQKNNWTQSDLAKRIGIKQATISNFENNPDNTTLTTFFRILQSLGMTMALYEKDDAASGSD
NNIQQGLDW

Download         Length: 270 bp

>AT25626 NC_015968:2353904-2354173 [Enterobacter soli]
ATGAAACCACCAATGATTTATAGTCCTGTCCAGCTGGCGAATACCATGAGACTGGTGCGTCAGAAAAATAACTGGACGCA
AAGCGACCTGGCCAAAAGAATCGGCATTAAGCAGGCCACCATCTCGAATTTTGAAAACAACCCGGATAACACCACGCTGA
CGACGTTCTTCAGGATCTTGCAATCCCTTGGAATGACCATGGCGTTGTATGAAAAAGACGATGCGGCGTCGGGGTCAGAC
AATAACATTCAACAGGGCCTGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References