Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2353904..2355492 Replicon chromosome
Accession NC_015968
Organism Enterobacter asburiae LF7a

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ENTAS_RS11025 Protein ID WP_014070315.1
Coordinates 2354173..2355492 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ENTAS_RS11020 Protein ID WP_014070314.1
Coordinates 2353904..2354173 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTAS_RS10990 2349119..2349877 - 759 WP_014070308.1 trans-aconitate 2-methyltransferase -
ENTAS_RS10995 2349960..2350544 - 585 WP_014070309.1 nucleoside diphosphate pyrophosphatase -
ENTAS_RS11000 2350632..2351405 + 774 WP_014070310.1 DeoR/GlpR family DNA-binding transcription regulator -
ENTAS_RS11005 2351377..2351868 - 492 WP_176408561.1 ATP-binding protein -
ENTAS_RS11010 2351967..2352320 + 354 WP_014070312.1 hypothetical protein -
ENTAS_RS11015 2352462..2353754 + 1293 WP_014070313.1 glycoside hydrolase -
ENTAS_RS11020 2353904..2354173 + 270 WP_014070314.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ENTAS_RS11025 2354173..2355492 + 1320 WP_014070315.1 type II toxin-antitoxin system HipA family toxin Toxin
ENTAS_RS11030 2355943..2356230 + 288 WP_014070316.1 VF530 family protein -
ENTAS_RS11035 2356237..2357529 + 1293 WP_014070317.1 glycoside hydrolase family 10 protein -
ENTAS_RS11040 2357609..2358370 - 762 WP_014070318.1 thiol:disulfide interchange protein DsbG -
ENTAS_RS11045 2358504..2359193 - 690 WP_014070319.1 VIT family protein -
ENTAS_RS11050 2359274..2359855 - 582 WP_041162230.1 cytochrome b/b6 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49030.13 Da        Isoelectric Point: 7.1625

>T25626 WP_014070315.1 NC_015968:2354173-2355492 [Enterobacter soli]
MPKLVTWMNNERVGELTKLTNGAHTFKYANEWLLNRYARPLSLSLPLQYGEITSDAVFNFFDNLLPDSPAVRDRIVKRYH
ARSRQPFDLLAEVGRDSVGAVTLLPANENSTTPEMMWETLSEEKLEKVLTAYQSDIPLGMINEENDFRISVAGAQEKTAL
LKAGDDWCIPKGITPTTHIIKLPIGEIKQPNATLDLSDSVDNEYFCLQLARALGIDVPNAEIIRAGRVRALAVERFDRRW
NASRSVLLRLPQEDMCQTFGLPSSVKYESDGGPGIPHIMAFLLGSSEALTDRYNFMKFQLFQWITGATDGHAKNFSIFIQ
PGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMSLNASKGRKNDIDKIYPRHFMATARAVRFPENQMTEIMQEFISDVP
QALDAVMKSLPTDFSQKVATSISRNVLRLHGRLSKSAGG

Download         Length: 1320 bp

>T25626 NC_015968:2354173-2355492 [Enterobacter soli]
ATGCCAAAATTAGTGACGTGGATGAATAACGAACGGGTCGGCGAACTGACAAAACTGACCAATGGGGCACATACGTTTAA
ATACGCCAATGAATGGCTACTTAACCGGTATGCCCGGCCATTGTCGTTATCGCTTCCGCTACAATATGGCGAAATTACCT
CCGATGCGGTGTTCAATTTCTTCGACAACCTGCTCCCGGATAGCCCGGCGGTCAGGGATCGTATTGTTAAGCGCTACCAT
GCCCGTTCCAGGCAACCCTTTGATTTACTGGCAGAGGTAGGGCGTGACAGCGTCGGCGCGGTGACGTTATTACCCGCTAA
TGAAAACAGCACGACACCGGAAATGATGTGGGAGACTCTGAGCGAAGAGAAACTCGAGAAGGTGTTGACGGCTTATCAGT
CAGACATCCCACTGGGGATGATTAATGAGGAAAATGATTTCCGCATTTCCGTTGCTGGCGCTCAGGAAAAAACAGCGCTC
CTTAAAGCCGGTGACGACTGGTGTATTCCGAAAGGTATCACGCCCACCACCCATATCATCAAGCTGCCGATTGGCGAGAT
AAAACAGCCCAATGCCACGCTGGATTTGAGCGATAGTGTGGATAATGAATACTTCTGTTTGCAGCTGGCCAGAGCGCTGG
GAATTGACGTGCCGAATGCGGAAATCATCAGAGCGGGCAGGGTGCGGGCACTTGCCGTCGAGCGTTTTGACCGCCGATGG
AACGCAAGCCGATCTGTTTTATTGCGCTTACCGCAGGAAGATATGTGCCAGACTTTTGGGCTTCCTTCGTCCGTGAAGTA
TGAGTCTGATGGCGGCCCCGGTATTCCACATATCATGGCATTTTTACTGGGTTCCAGCGAAGCGCTTACCGATCGTTATA
ATTTCATGAAATTCCAGCTATTTCAGTGGATAACAGGCGCAACCGATGGACATGCCAAGAACTTCTCAATATTCATCCAG
CCTGGCGGAAGCTATCGACTGACCCCGTTCTACGACATCATTTCGGCGTTTCCTGTGCTGGGCGGCGCCGGGATCCACAT
CAGCGATCTGAAACTGGCCATGAGCCTGAATGCCTCAAAAGGCCGTAAAAACGATATCGACAAGATCTATCCGAGACATT
TTATGGCAACAGCCAGGGCCGTCAGGTTTCCTGAAAACCAGATGACCGAGATTATGCAGGAATTTATCAGCGATGTGCCG
CAGGCACTGGATGCAGTGATGAAGTCTTTACCCACGGACTTTTCGCAAAAAGTCGCGACCTCGATATCCAGGAATGTGCT
CAGGCTGCATGGCCGACTGAGCAAAAGTGCAGGGGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10109.47 Da        Isoelectric Point: 8.5467

>AT25626 WP_014070314.1 NC_015968:2353904-2354173 [Enterobacter soli]
MKPPMIYSPVQLANTMRLVRQKNNWTQSDLAKRIGIKQATISNFENNPDNTTLTTFFRILQSLGMTMALYEKDDAASGSD
NNIQQGLDW

Download         Length: 270 bp

>AT25626 NC_015968:2353904-2354173 [Enterobacter soli]
ATGAAACCACCAATGATTTATAGTCCTGTCCAGCTGGCGAATACCATGAGACTGGTGCGTCAGAAAAATAACTGGACGCA
AAGCGACCTGGCCAAAAGAATCGGCATTAAGCAGGCCACCATCTCGAATTTTGAAAACAACCCGGATAACACCACGCTGA
CGACGTTCTTCAGGATCTTGCAATCCCTTGGAATGACCATGGCGTTGTATGAAAAAGACGATGCGGCGTCGGGGTCAGAC
AATAACATTCAACAGGGCCTGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References