Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1821435..1822270 Replicon chromosome
Accession NZ_CP103704
Organism Escherichia coli strain ST361

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag M5T41_RS08585 Protein ID WP_064221650.1
Coordinates 1821435..1821812 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag M5T41_RS08590 Protein ID WP_001295723.1
Coordinates 1821902..1822270 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T41_RS08550 (1816955) 1816955..1817428 + 474 WP_001105407.1 DNA gyrase inhibitor SbmC -
M5T41_RS08555 (1817626) 1817626..1818684 + 1059 WP_001200895.1 FUSC family protein -
M5T41_RS08560 (1818856) 1818856..1819185 + 330 WP_000450409.1 DUF496 family protein -
M5T41_RS08565 (1819286) 1819286..1819651 - 366 WP_001280454.1 EutP/PduV family microcompartment system protein -
M5T41_RS08570 (1819922) 1819922..1820311 - 390 WP_077875581.1 transposase -
M5T41_RS08575 (1821109) 1821109..1821189 - 81 Protein_1676 hypothetical protein -
M5T41_RS08580 (1821289) 1821289..1821438 - 150 Protein_1677 DUF5983 family protein -
M5T41_RS08585 (1821435) 1821435..1821812 - 378 WP_064221650.1 TA system toxin CbtA family protein Toxin
M5T41_RS08590 (1821902) 1821902..1822270 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T41_RS08595 (1822433) 1822433..1822654 - 222 WP_000692345.1 DUF987 domain-containing protein -
M5T41_RS08600 (1822717) 1822717..1823193 - 477 WP_001186775.1 RadC family protein -
M5T41_RS08605 (1823209) 1823209..1823694 - 486 WP_000849588.1 antirestriction protein -
M5T41_RS08610 (1823749) 1823749..1824567 - 819 WP_072649824.1 DUF932 domain-containing protein -
M5T41_RS08615 (1824685) 1824685..1824880 - 196 Protein_1684 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14150.14 Da        Isoelectric Point: 7.3249

>T256254 WP_064221650.1 NZ_CP103704:c1821812-1821435 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTQLARLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT256254 WP_001295723.1 NZ_CP103704:c1822270-1821902 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References