Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1052661..1053282 Replicon chromosome
Accession NC_015968
Organism Enterobacter asburiae LF7a

Toxin (Protein)


Gene name Hha Uniprot ID A0A198GT90
Locus tag ENTAS_RS04975 Protein ID WP_014069157.1
Coordinates 1052661..1052879 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag ENTAS_RS04980 Protein ID WP_008499288.1
Coordinates 1052908..1053282 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTAS_RS04945 1048671..1048931 + 261 WP_014069152.1 type B 50S ribosomal protein L31 -
ENTAS_RS04950 1048934..1049074 + 141 WP_006818844.1 type B 50S ribosomal protein L36 -
ENTAS_RS04955 1049071..1049781 - 711 WP_014069153.1 GNAT family N-acetyltransferase -
ENTAS_RS04960 1049881..1051341 + 1461 WP_014069154.1 PLP-dependent aminotransferase family protein -
ENTAS_RS04965 1051313..1051780 - 468 WP_014069155.1 membrane protein -
ENTAS_RS04970 1051897..1052448 - 552 WP_014069156.1 maltose O-acetyltransferase -
ENTAS_RS04975 1052661..1052879 - 219 WP_014069157.1 hemolysin expression modulator Hha Toxin
ENTAS_RS04980 1052908..1053282 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
ENTAS_RS04985 1053795..1056941 - 3147 WP_014069158.1 multidrug efflux RND transporter permease subunit -
ENTAS_RS04990 1056964..1058157 - 1194 WP_014069159.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8579.94 Da        Isoelectric Point: 8.9008

>T25625 WP_014069157.1 NC_015968:c1052879-1052661 [Enterobacter soli]
MSDKPLTKIDYLLRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T25625 NC_015968:c1052879-1052661 [Enterobacter soli]
ATGTCTGATAAACCATTAACCAAAATCGATTATTTGCTGCGTTTGCGACGTTGTCAGTCAATAGACACGCTTGAACGTGT
TATTGAAAAAAATAAATACGAGCTTTCTGATAATGAACTGGCTGTATTTTATTCAGCGGCTGACCACCGTCTTGCAGAAC
TCACCATGAATAAGTTGTATGACAAAATCCCTTCTTCTGTATGGAAGTTTGTACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT25625 WP_008499288.1 NC_015968:c1053282-1052908 [Enterobacter soli]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT25625 NC_015968:c1053282-1052908 [Enterobacter soli]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCACGGCTGGGTGAATGATCCAACGTCTGCCATCAATTTACAGCTAAATGAGTTGATAGAGC
ATATAGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAACTGATTGAGCAAATTGACGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGCCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCGAACCCTGTTAGCTTATCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A198GT90

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References