Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4771968..4772484 Replicon chromosome
Accession NZ_CP103699
Organism Klebsiella pneumoniae strain ST307

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5R30_RS23215 Protein ID WP_004178374.1
Coordinates 4771968..4772252 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag M5R30_RS23220 Protein ID WP_032434351.1
Coordinates 4772242..4772484 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R30_RS23190 (4767451) 4767451..4767714 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M5R30_RS23195 (4767844) 4767844..4768017 + 174 WP_032414379.1 hypothetical protein -
M5R30_RS23200 (4768020) 4768020..4768763 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5R30_RS23205 (4769120) 4769120..4771258 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5R30_RS23210 (4771500) 4771500..4771964 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5R30_RS23215 (4771968) 4771968..4772252 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R30_RS23220 (4772242) 4772242..4772484 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5R30_RS23225 (4772562) 4772562..4774472 - 1911 WP_004152270.1 PRD domain-containing protein -
M5R30_RS23230 (4774495) 4774495..4775649 - 1155 WP_002886900.1 lactonase family protein -
M5R30_RS23235 (4775715) 4775715..4776455 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T256244 WP_004178374.1 NZ_CP103699:c4772252-4771968 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT256244 WP_032434351.1 NZ_CP103699:c4772484-4772242 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References