Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4679240..4679943 Replicon chromosome
Accession NZ_CP103699
Organism Klebsiella pneumoniae strain ST307

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M5R30_RS22820 Protein ID WP_071994632.1
Coordinates 4679240..4679581 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M5R30_RS22825 Protein ID WP_032434296.1
Coordinates 4679602..4679943 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R30_RS22810 (4675555) 4675555..4676424 + 870 WP_023317468.1 HNH endonuclease -
M5R30_RS22815 (4677015) 4677015..4679048 + 2034 WP_050598589.1 hypothetical protein -
M5R30_RS22820 (4679240) 4679240..4679581 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M5R30_RS22825 (4679602) 4679602..4679943 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5R30_RS22830 (4679954) 4679954..4680496 - 543 WP_032434298.1 DNA repair protein RadC -
M5R30_RS22835 (4680509) 4680509..4680949 - 441 WP_032434300.1 antirestriction protein -
M5R30_RS22840 (4680980) 4680980..4681801 - 822 WP_032434301.1 DUF932 domain-containing protein -
M5R30_RS22845 (4681921) 4681921..4682394 - 474 WP_032434303.1 hypothetical protein -
M5R30_RS22850 (4682466) 4682466..4682918 - 453 WP_032410767.1 hypothetical protein -
M5R30_RS22855 (4682954) 4682954..4683670 - 717 WP_032434305.1 WYL domain-containing protein -
M5R30_RS22860 (4683914) 4683914..4684788 - 875 Protein_4478 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4667537..4713210 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T256243 WP_071994632.1 NZ_CP103699:c4679581-4679240 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT256243 WP_032434296.1 NZ_CP103699:c4679943-4679602 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References