Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2646463..2648051 Replicon chromosome
Accession NZ_CP103699
Organism Klebsiella pneumoniae strain ST307

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag M5R30_RS12970 Protein ID WP_004892016.1
Coordinates 2646463..2647785 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5R30_RS12975 Protein ID WP_004176198.1
Coordinates 2647785..2648051 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R30_RS12955 (2641519) 2641519..2644020 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
M5R30_RS12960 (2644008) 2644008..2645012 + 1005 WP_032435338.1 fimbrial protein -
M5R30_RS12965 (2645154) 2645154..2646446 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M5R30_RS12970 (2646463) 2646463..2647785 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
M5R30_RS12975 (2647785) 2647785..2648051 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5R30_RS12980 (2648438) 2648438..2648764 - 327 WP_004184023.1 hydroxyisourate hydrolase -
M5R30_RS12985 (2648761) 2648761..2649261 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5R30_RS12990 (2649239) 2649239..2650618 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
M5R30_RS12995 (2650964) 2650964..2652118 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5R30_RS13000 (2652099) 2652099..2653022 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T256240 WP_004892016.1 NZ_CP103699:c2647785-2646463 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT256240 WP_004176198.1 NZ_CP103699:c2648051-2647785 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References