Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 159985..160589 Replicon chromosome
Accession NC_015968
Organism Enterobacter asburiae LF7a

Toxin (Protein)


Gene name hicA Uniprot ID A0A198GW36
Locus tag ENTAS_RS00770 Protein ID WP_014068393.1
Coordinates 159985..160170 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A198GWZ2
Locus tag ENTAS_RS00775 Protein ID WP_014068394.1
Coordinates 160185..160589 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENTAS_RS00750 155052..156203 + 1152 WP_014068389.1 L-threonine dehydrogenase -
ENTAS_RS00755 156289..157827 + 1539 WP_014068390.1 aldehyde dehydrogenase AldB -
ENTAS_RS00760 157824..158786 - 963 WP_041162168.1 LysR family transcriptional regulator -
ENTAS_RS00765 158907..159647 + 741 WP_014068392.1 MipA/OmpV family protein -
ENTAS_RS00770 159985..160170 + 186 WP_014068393.1 type II toxin-antitoxin system HicA family toxin Toxin
ENTAS_RS00775 160185..160589 + 405 WP_014068394.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ENTAS_RS00780 160633..162582 - 1950 WP_014068395.1 glycoside hydrolase family 127 protein -
ENTAS_RS00785 162593..163993 - 1401 WP_014068396.1 MFS transporter -
ENTAS_RS00790 164218..165042 + 825 WP_014068397.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6871.13 Da        Isoelectric Point: 11.2509

>T25624 WP_014068393.1 NC_015968:159985-160170 [Enterobacter soli]
VKSADVITILVGHGWKCIRTKGSHHQFRHPVYKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T25624 NC_015968:159985-160170 [Enterobacter soli]
GTGAAAAGTGCGGACGTCATTACCATTCTGGTCGGTCATGGCTGGAAATGCATAAGAACGAAAGGAAGCCATCATCAGTT
CCGCCATCCGGTATATAAAGGGCTGGTAACAGTTCCTCATCCTAAAAAAGACATTAAACCTGGAACTCTCGCGCAAATCT
GGCGGCAGGCGGGCATCAAACATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14892.71 Da        Isoelectric Point: 4.3744

>AT25624 WP_014068394.1 NC_015968:160185-160589 [Enterobacter soli]
MFYPAYIHSDLNGSASGFFPDVPGCFFAGDSLDDAFQDARAALTAHFETLFESDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT25624 NC_015968:160185-160589 [Enterobacter soli]
ATGTTTTATCCGGCTTATATTCATTCTGACCTCAACGGAAGCGCCAGTGGCTTTTTTCCTGATGTGCCAGGCTGTTTTTT
TGCGGGAGATTCTCTGGATGACGCTTTTCAGGACGCTCGTGCGGCGTTGACTGCTCACTTTGAAACGCTGTTCGAAAGTG
ATGAAGAGCTCCCTTTGCCCGGCAATGTTGAGGCACATCTTGAGGCAACACCCGGTGATTTTATCGGTGGGCAGTGGCTG
CTGGTGGACATTAATATGAAGCAGTTTGACGGCAGGGCTGAGCGTATTAATATCACCATGCCCCGTCGTTTGTTGGTTAA
GATCGATTCCTTTGTCAGCGAACATCCCCAGTTCAGCAACCGGAGTGCATTCCTGGCAGAGGCAGCACGTCGAGTACTGC
CCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A198GW36

Antitoxin

Source ID Structure
AlphaFold DB A0A198GWZ2

References