Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5035836..5036493 Replicon chromosome
Accession NZ_CP103697
Organism Klebsiella pneumoniae strain ST3576

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5R27_RS24380 Protein ID WP_002916310.1
Coordinates 5036083..5036493 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5R27_RS24375 Protein ID WP_002916312.1
Coordinates 5035836..5036102 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R27_RS24350 (M5R27_24350) 5030992..5032425 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M5R27_RS24355 (M5R27_24355) 5032544..5033272 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5R27_RS24360 (M5R27_24360) 5033322..5033633 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
M5R27_RS24365 (M5R27_24365) 5033797..5034456 + 660 WP_002916317.1 hemolysin III family protein -
M5R27_RS24370 (M5R27_24370) 5034607..5035590 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
M5R27_RS24375 (M5R27_24375) 5035836..5036102 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5R27_RS24380 (M5R27_24380) 5036083..5036493 + 411 WP_002916310.1 protein YgfX Toxin
M5R27_RS24385 (M5R27_24385) 5036500..5037021 - 522 WP_004144730.1 flavodoxin FldB -
M5R27_RS24390 (M5R27_24390) 5037122..5038018 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5R27_RS24395 (M5R27_24395) 5038041..5038754 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5R27_RS24400 (M5R27_24400) 5038760..5040493 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T256230 WP_002916310.1 NZ_CP103697:5036083-5036493 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT256230 WP_002916312.1 NZ_CP103697:5035836-5036102 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References