Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 70562..71224 Replicon chromosome
Accession NC_015968
Organism Enterobacter asburiae LF7a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ENTAS_RS00335 Protein ID WP_014068311.1
Coordinates 70826..71224 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A198GX98
Locus tag ENTAS_RS00330 Protein ID WP_014068310.1
Coordinates 70562..70825 (+) Length 88 a.a.

Genomic Context

ENTAS_RS00315ENTAS_RS00325ENTAS_RS00330ENTAS_RS00335ENTAS_RS00340ENTAS_RS00345ENTAS_RS00350ENTAS_RS00305ENTAS_RS00310ENTAS_RS00320ENTAS_RS00355
Location: 67800..68219 (420 bp)
Type: Others
Protein ID: WP_014068307.1
Location: 68942..70444 (1503 bp)
Type: Others
Protein ID: WP_041161974.1
Location: 70562..70825 (264 bp)
Type: Antitoxin
Protein ID: WP_014068310.1
Location: 70826..71224 (399 bp)
Type: Toxin
Protein ID: WP_014068311.1
Location: 71411..72211 (801 bp)
Type: Others
Protein ID: WP_014068312.1
Location: 72336..73115 (780 bp)
Type: Others
Protein ID: WP_014068313.1
Location: 73142..74095 (954 bp)
Type: Others
Protein ID: WP_014068314.1
Location: 65774..66895 (1122 bp)
Type: Others
Protein ID: WP_014068305.1
Location: 67044..67613 (570 bp)
Type: Others
Protein ID: WP_014068306.1
Location: 68216..68863 (648 bp)
Type: Others
Protein ID: WP_014068308.1
Location: 74124..75212 (1089 bp)
Type: Others
Protein ID: WP_041161975.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ENTAS_RS0030565774..66895-1122WP_014068305.1efflux RND transporter periplasmic adaptor subunit-
ENTAS_RS0031067044..67613-570WP_014068306.1TetR/AcrR family transcriptional regulator-
ENTAS_RS0031567800..68219+420WP_014068307.1GNAT family N-acetyltransferase-
ENTAS_RS0032068216..68863-648WP_014068308.1TetR/AcrR family transcriptional regulator-
ENTAS_RS0032568942..70444+1503WP_041161974.1MFS transporter-
ENTAS_RS0033070562..70825+264WP_014068310.1virulence proteinAntitoxin
ENTAS_RS0033570826..71224+399WP_014068311.1type II toxin-antitoxin system VapC family toxinToxin
ENTAS_RS0034071411..72211+801WP_014068312.1lipoprotein NlpA-
ENTAS_RS0034572336..73115+780WP_014068313.1MBL fold metallo-hydrolase-
ENTAS_RS0035073142..74095+954WP_014068314.1helix-turn-helix domain-containing protein-
ENTAS_RS0035574124..75212-1089WP_041161975.1AAA family ATPase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14743.98 Da        Isoelectric Point: 5.8943

>T25623 WP_014068311.1 NC_015968:70826-71224 [Enterobacter soli]
MRHMLDTNMVSHLVKQHPAVVNQYSRIAPEEMCISSVTEAELLYGIAKKQSITLQETILEFLKTITICHWDSDAAAIYGK
LRADMEKRGKVMGDLDQLIAAHAISRGTTVVTNDHAFAMVQDLTVEDWTTVA

Download         Length: 399 bp

>T25623 NC_015968:70826-71224 [Enterobacter soli]
ATGCGGCATATGCTGGATACAAACATGGTGAGCCACCTGGTAAAGCAACATCCTGCGGTGGTCAATCAATATTCCCGAAT
AGCGCCCGAAGAAATGTGTATTTCAAGCGTAACGGAGGCCGAGTTGCTTTATGGCATTGCCAAAAAGCAGAGCATTACAT
TACAAGAAACCATCCTGGAATTTCTTAAAACCATCACCATTTGTCACTGGGACAGTGACGCCGCAGCCATTTACGGCAAA
CTGCGTGCAGACATGGAAAAGCGTGGAAAAGTGATGGGCGATCTCGACCAGCTGATTGCCGCACACGCGATCAGCAGGGG
AACCACGGTGGTCACTAACGATCACGCTTTCGCGATGGTGCAGGATCTTACGGTAGAGGACTGGACTACCGTTGCCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10198.62 Da        Isoelectric Point: 10.0414

>AT25623 WP_014068310.1 NC_015968:70562-70825 [Enterobacter soli]
MERKAKLFKKGRNQAVVLPAEFAFDTENVYIRRDEQGNVVLTAMSEKARHREIFLRLLKQTHVPDSFLSKEERNQSYTTR
DPFAGLE

Download         Length: 264 bp

>AT25623 NC_015968:70562-70825 [Enterobacter soli]
ATGGAACGCAAAGCAAAGCTATTTAAAAAGGGGCGAAATCAGGCCGTTGTTCTGCCTGCGGAATTCGCATTTGATACAGA
GAATGTTTATATCCGTCGGGATGAGCAGGGGAATGTTGTTCTGACGGCAATGTCAGAGAAAGCGCGGCACAGGGAAATCT
TTTTGCGTTTACTAAAACAGACGCATGTGCCTGATTCGTTTCTGAGTAAAGAGGAACGCAATCAAAGCTATACGACAAGA
GATCCTTTTGCAGGGCTAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A198GX98

References