Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4370128..4370867 Replicon chromosome
Accession NZ_CP103697
Organism Klebsiella pneumoniae strain ST3576

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag M5R27_RS21070 Protein ID WP_021312536.1
Coordinates 4370382..4370867 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag M5R27_RS21065 Protein ID WP_003026799.1
Coordinates 4370128..4370394 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R27_RS21050 (M5R27_21050) 4366772..4368141 + 1370 WP_087830479.1 IS3 family transposase -
M5R27_RS21060 (M5R27_21060) 4369567..4369995 + 429 WP_004901287.1 GFA family protein -
M5R27_RS21065 (M5R27_21065) 4370128..4370394 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
M5R27_RS21070 (M5R27_21070) 4370382..4370867 + 486 WP_021312536.1 GNAT family N-acetyltransferase Toxin
M5R27_RS21075 (M5R27_21075) 4371211..4371363 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
M5R27_RS21080 (M5R27_21080) 4371665..4373284 + 1620 WP_040221779.1 ATP-binding cassette domain-containing protein -
M5R27_RS21085 (M5R27_21085) 4373383..4373595 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
M5R27_RS21090 (M5R27_21090) 4373848..4374138 - 291 WP_002921931.1 HTH-type transcriptional regulator -
M5R27_RS21095 (M5R27_21095) 4374384..4375739 - 1356 WP_002921930.1 aromatic acid/H+ symport family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17608.39 Da        Isoelectric Point: 10.3370

>T256227 WP_021312536.1 NZ_CP103697:4370382-4370867 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT256227 WP_003026799.1 NZ_CP103697:4370128-4370394 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References