Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3712435..3714116 Replicon chromosome
Accession NZ_CP103697
Organism Klebsiella pneumoniae strain ST3576

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag M5R27_RS17945 Protein ID WP_019724882.1
Coordinates 3712435..3713352 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M5R27_RS17950 Protein ID WP_004177809.1
Coordinates 3713358..3714116 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R27_RS17925 (M5R27_17925) 3707741..3709261 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M5R27_RS17930 (M5R27_17930) 3709258..3710256 + 999 WP_002885172.1 ribose ABC transporter permease -
M5R27_RS17935 (M5R27_17935) 3710287..3711228 + 942 WP_121915345.1 ABC transporter substrate-binding protein -
M5R27_RS17940 (M5R27_17940) 3711303..3712310 + 1008 WP_015959270.1 carbohydrate kinase family protein -
M5R27_RS17945 (M5R27_17945) 3712435..3713352 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M5R27_RS17950 (M5R27_17950) 3713358..3714116 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M5R27_RS17955 (M5R27_17955) 3714202..3714930 - 729 WP_002885152.1 response regulator transcription factor -
M5R27_RS17960 (M5R27_17960) 3715203..3717350 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
M5R27_RS17965 (M5R27_17965) 3717580..3718266 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T256225 WP_019724882.1 NZ_CP103697:c3713352-3712435 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT256225 WP_004177809.1 NZ_CP103697:c3714116-3713358 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References