Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3554729..3555245 Replicon chromosome
Accession NZ_CP103697
Organism Klebsiella pneumoniae strain ST3576

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5R27_RS17150 Protein ID WP_004178374.1
Coordinates 3554729..3555013 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M5R27_RS17155 Protein ID WP_002886901.1
Coordinates 3555003..3555245 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R27_RS17125 (M5R27_17125) 3550125..3550433 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
M5R27_RS17130 (M5R27_17130) 3550518..3550691 + 174 WP_004222159.1 hypothetical protein -
M5R27_RS17135 (M5R27_17135) 3550694..3551437 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5R27_RS17140 (M5R27_17140) 3551794..3553932 + 2139 WP_032415880.1 anaerobic ribonucleoside-triphosphate reductase -
M5R27_RS17145 (M5R27_17145) 3554261..3554725 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5R27_RS17150 (M5R27_17150) 3554729..3555013 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5R27_RS17155 (M5R27_17155) 3555003..3555245 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5R27_RS17160 (M5R27_17160) 3555323..3557233 - 1911 WP_009486549.1 PRD domain-containing protein -
M5R27_RS17165 (M5R27_17165) 3557256..3558410 - 1155 WP_032415878.1 lactonase family protein -
M5R27_RS17170 (M5R27_17170) 3558477..3559217 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T256224 WP_004178374.1 NZ_CP103697:c3555013-3554729 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT256224 WP_002886901.1 NZ_CP103697:c3555245-3555003 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References