Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1446514..1448102 Replicon chromosome
Accession NZ_CP103697
Organism Klebsiella pneumoniae strain ST3576

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag M5R27_RS07010 Protein ID WP_032414910.1
Coordinates 1446514..1447836 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M5R27_RS07015 Protein ID WP_002904790.1
Coordinates 1447836..1448102 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R27_RS06995 (M5R27_06995) 1441570..1444071 + 2502 WP_032414912.1 fimbria/pilus outer membrane usher protein -
M5R27_RS07000 (M5R27_07000) 1444059..1445063 + 1005 WP_004176196.1 fimbrial protein -
M5R27_RS07005 (M5R27_07005) 1445205..1446497 + 1293 WP_032414911.1 glycoside hydrolase family 10 protein -
M5R27_RS07010 (M5R27_07010) 1446514..1447836 - 1323 WP_032414910.1 type II toxin-antitoxin system HipA family toxin Toxin
M5R27_RS07015 (M5R27_07015) 1447836..1448102 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5R27_RS07020 (M5R27_07020) 1448368..1448694 - 327 WP_032414908.1 hydroxyisourate hydrolase -
M5R27_RS07025 (M5R27_07025) 1448691..1449191 - 501 WP_032414907.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5R27_RS07030 (M5R27_07030) 1449169..1450548 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
M5R27_RS07035 (M5R27_07035) 1450894..1452048 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5R27_RS07040 (M5R27_07040) 1452029..1452952 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49150.45 Da        Isoelectric Point: 7.5618

>T256221 WP_032414910.1 NZ_CP103697:c1447836-1446514 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGHDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT256221 WP_002904790.1 NZ_CP103697:c1448102-1447836 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References