Detailed information of TA system TA025622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 366278..366890
• Replicon: chromosome
• Accession: NC_015966
• Organism: Rhodothermus marinus SG0.5JP17-172

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: RHOM172_RS14780
• Protein ID: WP_014066046.1
• Coordinates: 366501..366890 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G2SH50
• Locus tag: RHOM172_RS01705
• Protein ID: WP_014066045.1
• Coordinates: 366278..366508 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RHOM172_RS01680	361389..362447	-	1059	WP_155815961.1	2-oxoacid:ferredoxin oxidoreductase subunit beta	-
RHOM172_RS01685	362622..364484	-	1863	WP_014066041.1	2-oxoacid:acceptor oxidoreductase subunit alpha	-
RHOM172_RS01690	364641..365024	+	384	WP_014066042.1	Co2+/Mg2+ efflux protein ApaG	-
RHOM172_RS01695	365028..365288	-	261	WP_014066043.1	hypothetical protein	-
RHOM172_RS01700	365370..366221	+	852	WP_029933178.1	thymidylate synthase	-
RHOM172_RS01705	366278..366508	+	231	WP_014066045.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RHOM172_RS14780	366501..366890	+	390	WP_014066046.1	type II toxin-antitoxin system VapC family toxin	Toxin
RHOM172_RS01710	366902..367444	+	543	WP_014066047.1	dihydrofolate reductase	-
RHOM172_RS01715	367554..370520	+	2967	WP_014066048.1	ribonucleoside-diphosphate reductase adenosylcobalamin-dependent	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-47)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14774.25 Da
• Isoelectric Point: 6.3771

>T25622 WP_014066046.1 NC_015966:366501-366890 [Rhodothermus marinus SG0.5JP17-172]
MPERYLLDTHVLLWVLFDPERIPERVRERLIDPHFEVYFSAASVWEIAIKAQIGRLKLTLDLNAIVEAAKHSGFEPLAIH
TEHAAKIVDLPLHHRDPFDRILVAQAIVEKARLLTADSALIKCQNVELI

Nucleotide

• Length: 390 bp

>T25622 NC_015966:366501-366890 [Rhodothermus marinus SG0.5JP17-172]
ATGCCTGAGCGCTATTTGCTCGATACACATGTATTGCTATGGGTTCTTTTTGATCCAGAACGAATTCCTGAACGCGTACG
CGAACGTCTTATTGATCCACACTTTGAGGTGTATTTCAGTGCAGCAAGTGTGTGGGAAATAGCTATAAAAGCACAGATTG
GACGACTGAAACTTACTCTTGACTTGAACGCCATCGTTGAAGCAGCCAAGCATTCAGGATTCGAGCCTCTGGCCATTCAC
ACAGAACATGCGGCAAAAATTGTAGACCTTCCTTTACATCATCGTGATCCGTTTGATCGCATACTGGTCGCTCAGGCTAT
TGTCGAAAAAGCCCGGCTTTTAACTGCGGACAGCGCATTGATTAAGTGCCAGAATGTGGAGTTGATTTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8387.93 Da
• Isoelectric Point: 11.3495

>AT25622 WP_014066045.1 NC_015966:366278-366508 [Rhodothermus marinus SG0.5JP17-172]
MRVVNIREARALLSRLITAVEQGEEVIITRAGRPVARLVPLRKPRKLGVLAGRMTIPEDFDAPLPEKILSAFEGNA

Nucleotide

• Length: 231 bp

>AT25622 NC_015966:366278-366508 [Rhodothermus marinus SG0.5JP17-172]
ATGCGGGTTGTCAACATCAGAGAAGCCCGGGCGCTTCTTTCTCGGTTGATCACTGCGGTGGAGCAGGGAGAGGAGGTCAT
CATTACGCGGGCGGGGCGTCCGGTCGCCAGACTGGTACCCCTGCGGAAGCCGCGAAAGCTGGGTGTGCTGGCGGGACGCA
TGACCATTCCCGAAGATTTCGACGCACCACTGCCGGAAAAAATTCTGTCCGCTTTTGAAGGAAATGCCTGA

Structures

Antitoxin

• AlphaFold DB: G2SH50