Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
| Location | 3970541..3971355 | Replicon | chromosome |
| Accession | NZ_CP103694 | ||
| Organism | Escherichia coli strain ST12468 | ||
Toxin (Protein)
| Gene name | yjhX | Uniprot ID | A0A6C9SL90 |
| Locus tag | M5T31_RS19490 | Protein ID | WP_001054375.1 |
| Coordinates | 3970541..3970798 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yjhQ | Uniprot ID | U9Z4B8 |
| Locus tag | M5T31_RS19495 | Protein ID | WP_001309181.1 |
| Coordinates | 3970810..3971355 (+) | Length | 182 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M5T31_RS19465 (3965829) | 3965829..3966935 | + | 1107 | WP_001299704.1 | N-acetylneuraminate epimerase | - |
| M5T31_RS19470 (3967000) | 3967000..3967980 | + | 981 | WP_000991455.1 | sialate O-acetylesterase | - |
| M5T31_RS19475 (3968090) | 3968090..3968295 | + | 206 | Protein_3811 | HNH endonuclease | - |
| M5T31_RS19480 (3968563) | 3968563..3969803 | - | 1241 | Protein_3812 | helicase YjhR | - |
| M5T31_RS19485 (3969919) | 3969919..3970050 | + | 132 | WP_001309182.1 | hypothetical protein | - |
| M5T31_RS19490 (3970541) | 3970541..3970798 | + | 258 | WP_001054375.1 | YjhX family toxin | Toxin |
| M5T31_RS19495 (3970810) | 3970810..3971355 | + | 546 | WP_001309181.1 | N-acetyltransferase | Antitoxin |
| M5T31_RS19500 (3971411) | 3971411..3972157 | + | 747 | WP_058905772.1 | class I SAM-dependent methyltransferase | - |
| M5T31_RS19505 (3972326) | 3972326..3972544 | + | 219 | Protein_3817 | hypothetical protein | - |
| M5T31_RS19510 (3972582) | 3972582..3972698 | + | 117 | Protein_3818 | VOC family protein | - |
| M5T31_RS19515 (3972943) | 3972943..3974064 | + | 1122 | WP_000010831.1 | M42 family metallopeptidase | - |
| M5T31_RS19520 (3974061) | 3974061..3974339 | + | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB SgcB | - |
| M5T31_RS19525 (3974351) | 3974351..3975664 | + | 1314 | WP_000460845.1 | PTS sugar transporter subunit IIC SgcC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimB | 3961846..3979579 | 17733 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9768.31 Da Isoelectric Point: 11.0090
>T256210 WP_001054375.1 NZ_CP103694:3970541-3970798 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QFDNR
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QFDNR
Download Length: 258 bp
Antitoxin
Download Length: 182 a.a. Molecular weight: 19938.86 Da Isoelectric Point: 6.3277
>AT256210 WP_001309181.1 NZ_CP103694:3970810-3971355 [Escherichia coli]
ITVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
ITVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
Download Length: 546 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6C9SL90 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9Z4B8 |