Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 147904..148708 Replicon plasmid pENTAS01
Accession NC_015963
Organism Enterobacter asburiae LF7a

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag ENTAS_RS23520 Protein ID WP_014063951.1
Coordinates 147904..148434 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A198GDR7
Locus tag ENTAS_RS23525 Protein ID WP_014063952.1
Coordinates 148439..148708 (-) Length 90 a.a.

Genomic Context

ENTAS_RS23495ENTAS_RS23500ENTAS_RS23515ENTAS_RS23520ENTAS_RS23525ENTAS_RS23530ENTAS_RS23535ENTAS_RS23540ENTAS_RS23545ENTAS_RS23555
Location: 143294..144460 (1167 bp)
Type: Others
Protein ID: WP_014063949.1
Location: 144460..145440 (981 bp)
Type: Others
Protein ID: WP_014063950.1
Location: 146644..147812 (1169 bp)
Type: Others
Protein ID: WP_088201860.1
Location: 147904..148434 (531 bp)
Type: Toxin
Protein ID: WP_014063951.1
Location: 148439..148708 (270 bp)
Type: Antitoxin
Protein ID: WP_014063952.1
Location: 149000..149800 (801 bp)
Type: Others
Protein ID: Protein_152
Location: 149952..151190 (1239 bp)
Type: Others
Protein ID: WP_041162338.1
Location: 151416..152126 (711 bp)
Type: Others
Protein ID: WP_049796706.1
Location: 152142..152910 (769 bp)
Type: Others
Protein ID: Protein_155
Location: 153264..153530 (267 bp)
Type: Others
Protein ID: WP_014063956.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ENTAS_RS23495143294..144460+1167WP_014063949.1plasmid-partitioning protein SopA-
ENTAS_RS23500144460..145440+981WP_014063950.1ParB/RepB/Spo0J family plasmid partition protein-
ENTAS_RS23515146644..147812+1169WP_088201860.1IS3 family transposase-
ENTAS_RS23520147904..148434-531WP_014063951.1GNAT family N-acetyltransferaseToxin
ENTAS_RS23525148439..148708-270WP_014063952.1DUF1778 domain-containing proteinAntitoxin
ENTAS_RS23530149000..149800-801Protein_152Tn3 family transposase-
ENTAS_RS23535149952..151190-1239WP_041162338.1IS91 family transposase-
ENTAS_RS23540151416..152126-711WP_049796706.1hypothetical protein-
ENTAS_RS23545152142..152910-769Protein_155tyrosine-type recombinase/integrase-
ENTAS_RS23555153264..153530-267WP_014063956.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-mgtC / mgtB1..166725166725
-insideIScluster/Tn--146644..1498033159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19807.62 Da        Isoelectric Point: 6.8639

>T25621 WP_014063951.1 NC_015963:c148434-147904 [Enterobacter soli]
VDGLKVEIFSEEVEYDLSNFDCGEEYLNTFLTDHLKRQHIGKVLRGYVLVTREDKPRVMGYYTLSGSCFEKEQLPSKTQQ
KRVPYKNVPSVTLGRLAIDKSIQRQGYGDALVTHAMKVVYLASQAVGIHGMFVEALNDNAKKFYLGLGFVQLKGANSNAL
FYPTKAIEELFGAQDE

Download         Length: 531 bp

>T25621 NC_015963:c148434-147904 [Enterobacter soli]
GTGGACGGTTTAAAGGTAGAGATTTTTTCTGAGGAAGTTGAATATGATTTAAGCAACTTCGATTGTGGCGAAGAGTACCT
TAATACTTTTCTCACTGACCACCTGAAACGCCAACACATCGGCAAAGTATTACGAGGTTATGTGCTCGTCACGAGAGAAG
ATAAGCCTCGTGTTATGGGGTACTACACGTTGTCCGGGAGCTGCTTCGAAAAAGAGCAGCTTCCAAGCAAAACGCAGCAA
AAACGAGTGCCCTATAAAAACGTACCGAGTGTTACTCTGGGGCGTTTGGCAATTGATAAAAGTATTCAACGCCAGGGTTA
TGGAGACGCGCTTGTAACACATGCCATGAAGGTTGTGTATCTTGCATCTCAAGCGGTAGGAATACATGGAATGTTCGTTG
AAGCGCTTAATGACAACGCCAAAAAATTCTACCTTGGATTAGGCTTCGTTCAGCTCAAGGGTGCGAACAGCAACGCCCTC
TTCTATCCAACCAAAGCGATAGAAGAGCTATTCGGAGCTCAAGACGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10192.65 Da        Isoelectric Point: 7.0167

>AT25621 WP_014063952.1 NC_015963:c148708-148439 [Enterobacter soli]
MSALKKQRIDLRLNEDDKSMIEEAAAMTNQSISQFMVSTASERAAEVIDQHRRLILNEESWNLVMEAISNPPAPNDRLKR
AAKRLQKLE

Download         Length: 270 bp

>AT25621 NC_015963:c148708-148439 [Enterobacter soli]
ATGTCAGCACTGAAGAAACAGCGCATCGATCTTAGATTAAACGAAGACGACAAAAGCATGATCGAAGAAGCCGCGGCTAT
GACTAACCAGTCAATTTCACAGTTTATGGTTAGCACAGCCTCTGAACGTGCAGCGGAAGTTATTGATCAGCACCGCCGCC
TGATTCTTAACGAGGAATCATGGAACCTGGTAATGGAAGCGATCAGTAACCCACCGGCACCGAACGATCGACTGAAACGA
GCTGCTAAGCGTCTCCAGAAATTGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A198GDR7

References