Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2380575..2381213 Replicon chromosome
Accession NZ_CP103694
Organism Escherichia coli strain ST12468

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag M5T31_RS11690 Protein ID WP_000813794.1
Coordinates 2381037..2381213 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5T31_RS11685 Protein ID WP_001270286.1
Coordinates 2380575..2380991 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T31_RS11665 (2375727) 2375727..2376668 - 942 WP_001251319.1 ABC transporter permease -
M5T31_RS11670 (2376669) 2376669..2377682 - 1014 WP_000220393.1 ABC transporter ATP-binding protein -
M5T31_RS11675 (2377700) 2377700..2378845 - 1146 WP_058905745.1 ABC transporter substrate-binding protein -
M5T31_RS11680 (2379090) 2379090..2380496 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M5T31_RS11685 (2380575) 2380575..2380991 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5T31_RS11690 (2381037) 2381037..2381213 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5T31_RS11695 (2381435) 2381435..2381665 + 231 WP_000494244.1 YncJ family protein -
M5T31_RS11700 (2381757) 2381757..2383718 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5T31_RS11705 (2383791) 2383791..2384327 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M5T31_RS11710 (2384419) 2384419..2385594 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T256206 WP_000813794.1 NZ_CP103694:c2381213-2381037 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT256206 WP_001270286.1 NZ_CP103694:c2380991-2380575 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References