Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 823697..824351 Replicon chromosome
Accession NZ_CP103694
Organism Escherichia coli strain ST12468

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag M5T31_RS04035 Protein ID WP_000244777.1
Coordinates 823944..824351 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5T31_RS04030 Protein ID WP_000354046.1
Coordinates 823697..823963 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T31_RS04005 (818866) 818866..819609 + 744 WP_000951962.1 SDR family oxidoreductase -
M5T31_RS04010 (819666) 819666..821099 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
M5T31_RS04015 (821144) 821144..821455 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
M5T31_RS04020 (821619) 821619..822278 + 660 WP_000250274.1 hemolysin III family protein -
M5T31_RS04025 (822474) 822474..823454 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
M5T31_RS04030 (823697) 823697..823963 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5T31_RS04035 (823944) 823944..824351 + 408 WP_000244777.1 protein YgfX Toxin
M5T31_RS04040 (824391) 824391..824912 - 522 WP_001055874.1 flavodoxin FldB -
M5T31_RS04045 (825024) 825024..825920 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5T31_RS04050 (825945) 825945..826655 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T31_RS04055 (826661) 826661..828394 + 1734 WP_000813201.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T256198 WP_000244777.1 NZ_CP103694:823944-824351 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT256198 WP_000354046.1 NZ_CP103694:823697-823963 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References