Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4802097..4802613 Replicon chromosome
Accession NZ_CP103687
Organism Klebsiella pneumoniae strain ST307

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5S48_RS23440 Protein ID WP_004178374.1
Coordinates 4802097..4802381 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag M5S48_RS23445 Protein ID WP_032434351.1
Coordinates 4802371..4802613 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S48_RS23415 (4797580) 4797580..4797843 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M5S48_RS23420 (4797973) 4797973..4798146 + 174 WP_032414379.1 hypothetical protein -
M5S48_RS23425 (4798149) 4798149..4798892 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5S48_RS23430 (4799249) 4799249..4801387 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5S48_RS23435 (4801629) 4801629..4802093 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S48_RS23440 (4802097) 4802097..4802381 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S48_RS23445 (4802371) 4802371..4802613 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S48_RS23450 (4802691) 4802691..4804601 - 1911 WP_004152270.1 PRD domain-containing protein -
M5S48_RS23455 (4804624) 4804624..4805778 - 1155 WP_002886900.1 lactonase family protein -
M5S48_RS23460 (4805844) 4805844..4806584 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T256191 WP_004178374.1 NZ_CP103687:c4802381-4802097 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT256191 WP_032434351.1 NZ_CP103687:c4802613-4802371 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References