Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4709369..4710072 Replicon chromosome
Accession NZ_CP103687
Organism Klebsiella pneumoniae strain ST307

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M5S48_RS23045 Protein ID WP_071994632.1
Coordinates 4709369..4709710 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M5S48_RS23050 Protein ID WP_032434296.1
Coordinates 4709731..4710072 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S48_RS23035 (4705684) 4705684..4706553 + 870 WP_023317468.1 HNH endonuclease -
M5S48_RS23040 (4707144) 4707144..4709177 + 2034 WP_259426111.1 hypothetical protein -
M5S48_RS23045 (4709369) 4709369..4709710 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M5S48_RS23050 (4709731) 4709731..4710072 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5S48_RS23055 (4710083) 4710083..4710625 - 543 WP_032434298.1 DNA repair protein RadC -
M5S48_RS23060 (4710638) 4710638..4711078 - 441 WP_032434300.1 antirestriction protein -
M5S48_RS23065 (4711109) 4711109..4711930 - 822 WP_032434301.1 DUF932 domain-containing protein -
M5S48_RS23070 (4712050) 4712050..4712523 - 474 WP_032434303.1 hypothetical protein -
M5S48_RS23075 (4712595) 4712595..4713047 - 453 WP_032410767.1 hypothetical protein -
M5S48_RS23080 (4713083) 4713083..4713799 - 717 WP_032434305.1 WYL domain-containing protein -
M5S48_RS23085 (4714043) 4714043..4714917 - 875 Protein_4523 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4697666..4743339 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T256190 WP_071994632.1 NZ_CP103687:c4709710-4709369 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT256190 WP_032434296.1 NZ_CP103687:c4710072-4709731 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References