Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795769..796426 Replicon chromosome
Accession NZ_CP103687
Organism Klebsiella pneumoniae strain ST307

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M5S48_RS03945 Protein ID WP_002916310.1
Coordinates 796016..796426 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M5S48_RS03940 Protein ID WP_002916312.1
Coordinates 795769..796035 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S48_RS03915 (790977) 790977..792410 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M5S48_RS03920 (792529) 792529..793257 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M5S48_RS03925 (793307) 793307..793618 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M5S48_RS03930 (793782) 793782..794441 + 660 WP_004174454.1 hemolysin III family protein -
M5S48_RS03935 (794540) 794540..795523 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
M5S48_RS03940 (795769) 795769..796035 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M5S48_RS03945 (796016) 796016..796426 + 411 WP_002916310.1 protein YgfX Toxin
M5S48_RS03950 (796433) 796433..796954 - 522 WP_002916308.1 flavodoxin FldB -
M5S48_RS03955 (797055) 797055..797951 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M5S48_RS03960 (797974) 797974..798687 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S48_RS03965 (798693) 798693..800426 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T256181 WP_002916310.1 NZ_CP103687:796016-796426 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT256181 WP_002916312.1 NZ_CP103687:795769-796035 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References