Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 273758..274659 Replicon plasmid pMB4528V_1
Accession NZ_CP103684
Organism Enterobacter hormaechei strain ST90

Toxin (Protein)


Gene name - Uniprot ID A0A330G4J7
Locus tag M5S84_RS24290 Protein ID WP_022652120.1
Coordinates 273758..274216 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag M5S84_RS24295 Protein ID WP_022652121.1
Coordinates 274213..274659 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S84_RS24265 (M5S84_24265) 270974..271420 - 447 WP_015063027.1 hypothetical protein -
M5S84_RS24270 (M5S84_24270) 271467..272273 - 807 WP_015063028.1 hypothetical protein -
M5S84_RS24275 (M5S84_24275) 272503..272766 - 264 WP_032610382.1 hypothetical protein -
M5S84_RS24280 (M5S84_24280) 272823..273155 - 333 WP_259409755.1 hypothetical protein -
M5S84_RS24285 (M5S84_24285) 273490..273720 - 231 WP_022652119.1 hypothetical protein -
M5S84_RS24290 (M5S84_24290) 273758..274216 - 459 WP_022652120.1 RES family NAD+ phosphorylase Toxin
M5S84_RS24295 (M5S84_24295) 274213..274659 - 447 WP_022652121.1 DUF2384 domain-containing protein Antitoxin
M5S84_RS24300 (M5S84_24300) 274736..275044 - 309 WP_022652122.1 hypothetical protein -
M5S84_RS24305 (M5S84_24305) 275220..276488 - 1269 WP_022652123.1 DNA methyltransferase -
M5S84_RS24310 (M5S84_24310) 276475..277086 - 612 WP_022652124.1 hypothetical protein -
M5S84_RS24315 (M5S84_24315) 277148..277783 - 636 WP_022652125.1 hypothetical protein -
M5S84_RS24320 (M5S84_24320) 277899..278156 - 258 WP_022652126.1 hypothetical protein -
M5S84_RS24325 (M5S84_24325) 278220..278654 - 435 WP_015063073.1 hypothetical protein -
M5S84_RS24330 (M5S84_24330) 278790..279167 - 378 WP_015063074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaSHV-12 / ant(2'')-Ia / catB3 / qacE / sul1 / qnrB17 vipA/tssB / vipB/tssC 1..398127 398127


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(95-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16758.14 Da        Isoelectric Point: 4.4843

>T256177 WP_022652120.1 NZ_CP103684:c274216-273758 [Enterobacter hormaechei]
VILYRMTKTRYITTAWSGLGAKEAGGRWNSVGTALVYLSETASLTMLETLVHINAPQLLDAYTLLSIDVPDDQIQAFDLN
LLPPGWASEDAPAELALYGDNWAESGSSVALRIPSALSPVEFNYLLNPAHPAIFDLMKTVQKIPYQYDTRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16606.03 Da        Isoelectric Point: 7.4048

>AT256177 WP_022652121.1 NZ_CP103684:c274659-274213 [Enterobacter hormaechei]
MTMKVFSPDLSKMNPHGLWQVVGLDNDGIALMDKISHGLEGKVAHSISEWANITPSELRKMSGIPNTTFNRSVKARFTAD
QSERLVRIIRVIERAVELFEGDKEAAQKWMNEPNRGLSWKTPADVVSSETGALEVMRLITRIEHGVYS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A330G4J7

Antitoxin

Source ID Structure

References