Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4674661..4675277 Replicon chromosome
Accession NZ_CP103683
Organism Enterobacter hormaechei strain ST90

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5S84_RS22335 Protein ID WP_077266491.1
Coordinates 4674661..4675032 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag M5S84_RS22340 Protein ID WP_015569912.1
Coordinates 4675035..4675277 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S84_RS22320 (M5S84_22320) 4672161..4673063 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
M5S84_RS22325 (M5S84_22325) 4673060..4673695 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
M5S84_RS22330 (M5S84_22330) 4673692..4674621 + 930 WP_006808712.1 formate dehydrogenase accessory protein FdhE -
M5S84_RS22335 (M5S84_22335) 4674661..4675032 - 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
M5S84_RS22340 (M5S84_22340) 4675035..4675277 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
M5S84_RS22345 (M5S84_22345) 4675476..4676396 + 921 WP_063847977.1 alpha/beta hydrolase -
M5S84_RS22350 (M5S84_22350) 4676405..4677346 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
M5S84_RS22355 (M5S84_22355) 4677391..4677828 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
M5S84_RS22360 (M5S84_22360) 4677825..4678706 - 882 WP_003861949.1 virulence factor BrkB family protein -
M5S84_RS22365 (M5S84_22365) 4678700..4679299 - 600 WP_003861947.1 glucose-1-phosphatase -
M5S84_RS22370 (M5S84_22370) 4679418..4680218 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T256175 WP_077266491.1 NZ_CP103683:c4675032-4674661 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT256175 WP_015569912.1 NZ_CP103683:c4675277-4675035 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References