Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4549156..4549760 Replicon chromosome
Accession NZ_CP103683
Organism Enterobacter hormaechei strain ST90

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag M5S84_RS21770 Protein ID WP_071788668.1
Coordinates 4549575..4549760 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag M5S84_RS21765 Protein ID WP_023295606.1
Coordinates 4549156..4549560 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S84_RS21750 (M5S84_21750) 4544696..4545514 - 819 WP_033488031.1 helix-turn-helix domain-containing protein -
M5S84_RS21755 (M5S84_21755) 4545740..4547140 + 1401 WP_033488030.1 MFS transporter -
M5S84_RS21760 (M5S84_21760) 4547151..4549100 + 1950 WP_033488029.1 glycoside hydrolase family 127 protein -
M5S84_RS21765 (M5S84_21765) 4549156..4549560 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M5S84_RS21770 (M5S84_21770) 4549575..4549760 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
M5S84_RS21775 (M5S84_21775) 4550010..4551548 - 1539 WP_033488028.1 aldehyde dehydrogenase AldB -
M5S84_RS21780 (M5S84_21780) 4551715..4552599 + 885 WP_003860164.1 ROK family protein -
M5S84_RS21785 (M5S84_21785) 4552603..4554441 - 1839 WP_058686522.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T256174 WP_071788668.1 NZ_CP103683:c4549760-4549575 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT256174 WP_023295606.1 NZ_CP103683:c4549560-4549156 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References