Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2319242..2319981 Replicon chromosome
Accession NZ_CP103683
Organism Enterobacter hormaechei strain ST90

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag M5S84_RS11065 Protein ID WP_045339804.1
Coordinates 2319242..2319727 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag M5S84_RS11070 Protein ID WP_003857131.1
Coordinates 2319715..2319981 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S84_RS11035 (M5S84_11035) 2314295..2315587 + 1293 WP_032671140.1 glycosyl hydrolase family 28 protein -
M5S84_RS11040 (M5S84_11040) 2315656..2316201 + 546 WP_032671141.1 NUDIX hydrolase -
M5S84_RS11045 (M5S84_11045) 2316385..2317020 - 636 WP_063847894.1 DUF421 domain-containing protein -
M5S84_RS11050 (M5S84_11050) 2317030..2317254 - 225 Protein_2156 DUF3290 family protein -
M5S84_RS11055 (M5S84_11055) 2317641..2318606 + 966 WP_058689390.1 hypothetical protein -
M5S84_RS11060 (M5S84_11060) 2318622..2319191 + 570 WP_063847895.1 hypothetical protein -
M5S84_RS11065 (M5S84_11065) 2319242..2319727 - 486 WP_045339804.1 GNAT family N-acetyltransferase Toxin
M5S84_RS11070 (M5S84_11070) 2319715..2319981 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
M5S84_RS11075 (M5S84_11075) 2320045..2320974 - 930 WP_063847896.1 LysR family transcriptional regulator -
M5S84_RS11080 (M5S84_11080) 2321104..2322486 + 1383 WP_033487775.1 MFS transporter -
M5S84_RS11085 (M5S84_11085) 2322508..2323503 - 996 WP_033487776.1 DUF2891 domain-containing protein -
M5S84_RS11090 (M5S84_11090) 2323513..2324499 - 987 WP_033487777.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.27 Da        Isoelectric Point: 9.9658

>T256165 WP_045339804.1 NZ_CP103683:c2319727-2319242 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAMMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT256165 WP_003857131.1 NZ_CP103683:c2319981-2319715 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References