Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1757632..1758429 Replicon chromosome
Accession NZ_CP103683
Organism Enterobacter hormaechei strain ST90

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag M5S84_RS08315 Protein ID WP_033487261.1
Coordinates 1757908..1758429 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A331QJY7
Locus tag M5S84_RS08310 Protein ID WP_015570876.1
Coordinates 1757632..1757901 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S84_RS08275 (M5S84_08275) 1753177..1753536 + 360 WP_017384779.1 helix-turn-helix domain-containing protein -
M5S84_RS08280 (M5S84_08280) 1753603..1753710 - 108 Protein_1607 transcriptional regulator -
M5S84_RS08285 (M5S84_08285) 1753865..1755106 + 1242 WP_033487264.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
M5S84_RS08290 (M5S84_08290) 1755139..1755366 - 228 WP_032670920.1 YccJ family protein -
M5S84_RS08295 (M5S84_08295) 1755385..1755981 - 597 WP_033487263.1 NAD(P)H:quinone oxidoreductase -
M5S84_RS08300 (M5S84_08300) 1756372..1756542 + 171 WP_001273664.1 general stress protein -
M5S84_RS08305 (M5S84_08305) 1756659..1757558 + 900 WP_033487262.1 DMT family transporter -
M5S84_RS08310 (M5S84_08310) 1757632..1757901 + 270 WP_015570876.1 DUF1778 domain-containing protein Antitoxin
M5S84_RS08315 (M5S84_08315) 1757908..1758429 + 522 WP_033487261.1 GNAT family N-acetyltransferase Toxin
M5S84_RS08320 (M5S84_08320) 1758488..1759810 - 1323 WP_032670921.1 pyrimidine utilization transport protein G -
M5S84_RS08325 (M5S84_08325) 1759832..1760323 - 492 WP_015570873.1 pyrimidine utilization flavin reductase protein F -
M5S84_RS08330 (M5S84_08330) 1760336..1760926 - 591 WP_017693662.1 malonic semialdehyde reductase -
M5S84_RS08335 (M5S84_08335) 1760936..1761736 - 801 WP_023296287.1 pyrimidine utilization protein D -
M5S84_RS08340 (M5S84_08340) 1761744..1762130 - 387 WP_015570870.1 pyrimidine utilization protein C -
M5S84_RS08345 (M5S84_08345) 1762142..1762831 - 690 WP_023296288.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19453.18 Da        Isoelectric Point: 7.4318

>T256164 WP_033487261.1 NZ_CP103683:1757908-1758429 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRILRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQS

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10247.75 Da        Isoelectric Point: 5.8836

>AT256164 WP_015570876.1 NZ_CP103683:1757632-1757901 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWIAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A331QJY7

References