Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1156145..1156765 Replicon chromosome
Accession NZ_CP103683
Organism Enterobacter hormaechei strain ST90

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag M5S84_RS05490 Protein ID WP_015571250.1
Coordinates 1156145..1156363 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag M5S84_RS05495 Protein ID WP_006809850.1
Coordinates 1156391..1156765 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S84_RS05460 (M5S84_05460) 1152157..1152417 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
M5S84_RS05465 (M5S84_05465) 1152420..1152560 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M5S84_RS05470 (M5S84_05470) 1152557..1153267 - 711 WP_033486653.1 GNAT family protein -
M5S84_RS05475 (M5S84_05475) 1153369..1154829 + 1461 WP_033486652.1 PLP-dependent aminotransferase family protein -
M5S84_RS05480 (M5S84_05480) 1154801..1155268 - 468 WP_023296041.1 YlaC family protein -
M5S84_RS05485 (M5S84_05485) 1155385..1155936 - 552 WP_015571251.1 maltose O-acetyltransferase -
M5S84_RS05490 (M5S84_05490) 1156145..1156363 - 219 WP_015571250.1 HHA domain-containing protein Toxin
M5S84_RS05495 (M5S84_05495) 1156391..1156765 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
M5S84_RS05500 (M5S84_05500) 1157276..1160422 - 3147 WP_033486650.1 multidrug efflux RND transporter permease subunit AcrB -
M5S84_RS05505 (M5S84_05505) 1160445..1161638 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T256162 WP_015571250.1 NZ_CP103683:c1156363-1156145 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT256162 WP_006809850.1 NZ_CP103683:c1156765-1156391 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References