Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 644221..644797 Replicon chromosome
Accession NZ_CP103683
Organism Enterobacter hormaechei strain ST90

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag M5S84_RS03075 Protein ID WP_015572580.1
Coordinates 644221..644508 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag M5S84_RS03080 Protein ID WP_017694570.1
Coordinates 644495..644797 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S84_RS03050 (M5S84_03050) 639314..640033 + 720 WP_050515874.1 winged helix-turn-helix domain-containing protein -
M5S84_RS03055 (M5S84_03055) 640183..640653 + 471 WP_033486706.1 MarR family transcriptional regulator -
M5S84_RS03060 (M5S84_03060) 640650..641717 + 1068 WP_026080654.1 HlyD family secretion protein -
M5S84_RS03065 (M5S84_03065) 641707..642783 + 1077 WP_015572578.1 DUF2955 domain-containing protein -
M5S84_RS03070 (M5S84_03070) 642780..644051 - 1272 WP_033486707.1 DUF445 domain-containing protein -
M5S84_RS03075 (M5S84_03075) 644221..644508 + 288 WP_015572580.1 BrnT family toxin Toxin
M5S84_RS03080 (M5S84_03080) 644495..644797 + 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
M5S84_RS03085 (M5S84_03085) 644826..645464 - 639 WP_033486708.1 LysE family translocator -
M5S84_RS03090 (M5S84_03090) 645503..646255 - 753 WP_033486709.1 AraC family transcriptional regulator -
M5S84_RS03095 (M5S84_03095) 646409..647779 + 1371 WP_033486710.1 NAD-dependent succinate-semialdehyde dehydrogenase -
M5S84_RS03100 (M5S84_03100) 647955..648500 - 546 WP_033486712.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T256161 WP_015572580.1 NZ_CP103683:644221-644508 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT256161 WP_017694570.1 NZ_CP103683:644495-644797 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References