Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 193029..193930 Replicon plasmid pMB4528_1
Accession NZ_CP103680
Organism Enterobacter hormaechei strain MB4528 Variant

Toxin (Protein)


Gene name - Uniprot ID A0A330G4J7
Locus tag M5T06_RS23675 Protein ID WP_022652120.1
Coordinates 193472..193930 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag M5T06_RS23670 Protein ID WP_022652121.1
Coordinates 193029..193475 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T06_RS23635 (M5T06_23635) 188521..188898 + 378 WP_015063074.1 hypothetical protein -
M5T06_RS23640 (M5T06_23640) 189034..189468 + 435 WP_015063073.1 hypothetical protein -
M5T06_RS23645 (M5T06_23645) 189532..189789 + 258 WP_022652126.1 hypothetical protein -
M5T06_RS23650 (M5T06_23650) 189905..190540 + 636 WP_022652125.1 hypothetical protein -
M5T06_RS23655 (M5T06_23655) 190602..191213 + 612 WP_022652124.1 hypothetical protein -
M5T06_RS23660 (M5T06_23660) 191200..192468 + 1269 WP_022652123.1 DNA methyltransferase -
M5T06_RS23665 (M5T06_23665) 192644..192952 + 309 WP_022652122.1 hypothetical protein -
M5T06_RS23670 (M5T06_23670) 193029..193475 + 447 WP_022652121.1 DUF2384 domain-containing protein Antitoxin
M5T06_RS23675 (M5T06_23675) 193472..193930 + 459 WP_022652120.1 RES family NAD+ phosphorylase Toxin
M5T06_RS23680 (M5T06_23680) 193968..194198 + 231 WP_022652119.1 hypothetical protein -
M5T06_RS23685 (M5T06_23685) 194533..194865 + 333 WP_259409755.1 hypothetical protein -
M5T06_RS23690 (M5T06_23690) 194922..195185 + 264 WP_032610382.1 hypothetical protein -
M5T06_RS23695 (M5T06_23695) 195415..196221 + 807 WP_015063028.1 hypothetical protein -
M5T06_RS23700 (M5T06_23700) 196268..196714 + 447 WP_015063027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qnrB17 / qacE / catB3 / ant(2'')-Ia / blaSHV-12 vipB/tssC / vipA/tssB 1..361069 361069


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(95-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16758.14 Da        Isoelectric Point: 4.4843

>T256158 WP_022652120.1 NZ_CP103680:193472-193930 [Enterobacter hormaechei]
VILYRMTKTRYITTAWSGLGAKEAGGRWNSVGTALVYLSETASLTMLETLVHINAPQLLDAYTLLSIDVPDDQIQAFDLN
LLPPGWASEDAPAELALYGDNWAESGSSVALRIPSALSPVEFNYLLNPAHPAIFDLMKTVQKIPYQYDTRLK

Download         Length: 459 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16606.03 Da        Isoelectric Point: 7.4048

>AT256158 WP_022652121.1 NZ_CP103680:193029-193475 [Enterobacter hormaechei]
MTMKVFSPDLSKMNPHGLWQVVGLDNDGIALMDKISHGLEGKVAHSISEWANITPSELRKMSGIPNTTFNRSVKARFTAD
QSERLVRIIRVIERAVELFEGDKEAAQKWMNEPNRGLSWKTPADVVSSETGALEVMRLITRIEHGVYS

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A330G4J7

Antitoxin

Source ID Structure

References