Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4673884..4674500 Replicon chromosome
Accession NZ_CP103679
Organism Enterobacter hormaechei strain MB4528 Variant

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5T06_RS22285 Protein ID WP_077266491.1
Coordinates 4673884..4674255 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag M5T06_RS22290 Protein ID WP_015569912.1
Coordinates 4674258..4674500 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T06_RS22270 (M5T06_22270) 4671384..4672286 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
M5T06_RS22275 (M5T06_22275) 4672283..4672918 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
M5T06_RS22280 (M5T06_22280) 4672915..4673844 + 930 WP_006808712.1 formate dehydrogenase accessory protein FdhE -
M5T06_RS22285 (M5T06_22285) 4673884..4674255 - 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
M5T06_RS22290 (M5T06_22290) 4674258..4674500 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
M5T06_RS22295 (M5T06_22295) 4674699..4675619 + 921 WP_063847977.1 alpha/beta hydrolase -
M5T06_RS22300 (M5T06_22300) 4675628..4676569 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
M5T06_RS22305 (M5T06_22305) 4676614..4677051 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
M5T06_RS22310 (M5T06_22310) 4677048..4677929 - 882 WP_003861949.1 virulence factor BrkB family protein -
M5T06_RS22315 (M5T06_22315) 4677923..4678522 - 600 WP_003861947.1 glucose-1-phosphatase -
M5T06_RS22320 (M5T06_22320) 4678641..4679441 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T256157 WP_077266491.1 NZ_CP103679:c4674255-4673884 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT256157 WP_015569912.1 NZ_CP103679:c4674500-4674258 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References