Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3751290..3751947 Replicon chromosome
Accession NZ_CP103679
Organism Enterobacter hormaechei strain MB4528 Variant

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag M5T06_RS17850 Protein ID WP_017382887.1
Coordinates 3751290..3751700 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag M5T06_RS17855 Protein ID WP_003863437.1
Coordinates 3751681..3751947 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T06_RS17830 (M5T06_17830) 3747288..3749021 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
M5T06_RS17835 (M5T06_17835) 3749027..3749740 - 714 WP_033487627.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T06_RS17840 (M5T06_17840) 3749769..3750665 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
M5T06_RS17845 (M5T06_17845) 3750767..3751288 + 522 WP_015571793.1 flavodoxin FldB -
M5T06_RS17850 (M5T06_17850) 3751290..3751700 - 411 WP_017382887.1 protein YgfX Toxin
M5T06_RS17855 (M5T06_17855) 3751681..3751947 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
M5T06_RS17860 (M5T06_17860) 3752242..3753222 + 981 WP_017692714.1 tRNA-modifying protein YgfZ -
M5T06_RS17865 (M5T06_17865) 3753334..3753993 - 660 WP_003863433.1 hemolysin III family protein -
M5T06_RS17870 (M5T06_17870) 3754260..3754991 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
M5T06_RS17875 (M5T06_17875) 3755108..3756541 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T256154 WP_017382887.1 NZ_CP103679:c3751700-3751290 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT256154 WP_003863437.1 NZ_CP103679:c3751947-3751681 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References