Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4754571..4755087 Replicon chromosome
Accession NZ_CP103676
Organism Klebsiella pneumoniae strain 2946

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M5S99_RS23050 Protein ID WP_004178374.1
Coordinates 4754571..4754855 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag M5S99_RS23055 Protein ID WP_032434351.1
Coordinates 4754845..4755087 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S99_RS23025 (4750054) 4750054..4750317 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M5S99_RS23030 (4750447) 4750447..4750620 + 174 WP_032414379.1 hypothetical protein -
M5S99_RS23035 (4750623) 4750623..4751366 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M5S99_RS23040 (4751723) 4751723..4753861 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M5S99_RS23045 (4754103) 4754103..4754567 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M5S99_RS23050 (4754571) 4754571..4754855 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S99_RS23055 (4754845) 4754845..4755087 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M5S99_RS23060 (4755165) 4755165..4757075 - 1911 WP_004152270.1 PRD domain-containing protein -
M5S99_RS23065 (4757098) 4757098..4758252 - 1155 WP_002886900.1 lactonase family protein -
M5S99_RS23070 (4758318) 4758318..4759058 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T256139 WP_004178374.1 NZ_CP103676:c4754855-4754571 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT256139 WP_032434351.1 NZ_CP103676:c4755087-4754845 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References