Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4661843..4662546 Replicon chromosome
Accession NZ_CP103676
Organism Klebsiella pneumoniae strain 2946

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag M5S99_RS22655 Protein ID WP_071994632.1
Coordinates 4661843..4662184 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag M5S99_RS22660 Protein ID WP_032434296.1
Coordinates 4662205..4662546 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S99_RS22645 (4658158) 4658158..4659027 + 870 WP_023317468.1 HNH endonuclease -
M5S99_RS22650 (4659618) 4659618..4661651 + 2034 WP_050598589.1 hypothetical protein -
M5S99_RS22655 (4661843) 4661843..4662184 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
M5S99_RS22660 (4662205) 4662205..4662546 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5S99_RS22665 (4662557) 4662557..4663099 - 543 WP_032434298.1 DNA repair protein RadC -
M5S99_RS22670 (4663112) 4663112..4663552 - 441 WP_032434300.1 antirestriction protein -
M5S99_RS22675 (4663583) 4663583..4664404 - 822 WP_032434301.1 DUF932 domain-containing protein -
M5S99_RS22680 (4664524) 4664524..4664997 - 474 WP_032434303.1 hypothetical protein -
M5S99_RS22685 (4665069) 4665069..4665521 - 453 WP_032410767.1 hypothetical protein -
M5S99_RS22690 (4665557) 4665557..4666273 - 717 WP_032434305.1 WYL domain-containing protein -
M5S99_RS22695 (4666517) 4666517..4667391 - 875 Protein_4447 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4650140..4695813 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T256138 WP_071994632.1 NZ_CP103676:c4662184-4661843 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT256138 WP_032434296.1 NZ_CP103676:c4662546-4662205 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References