Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4589063..4589679 Replicon chromosome
Accession NZ_CP103674
Organism Enterobacter hormaechei strain 1074

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M5T14_RS21820 Protein ID WP_045327153.1
Coordinates 4589063..4589434 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag M5T14_RS21825 Protein ID WP_015569912.1
Coordinates 4589437..4589679 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T14_RS21805 (M5T14_21805) 4586563..4587465 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
M5T14_RS21810 (M5T14_21810) 4587462..4588097 + 636 WP_003861958.1 formate dehydrogenase cytochrome b556 subunit -
M5T14_RS21815 (M5T14_21815) 4588094..4589023 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
M5T14_RS21820 (M5T14_21820) 4589063..4589434 - 372 WP_045327153.1 type II toxin-antitoxin system VapC family toxin Toxin
M5T14_RS21825 (M5T14_21825) 4589437..4589679 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
M5T14_RS21830 (M5T14_21830) 4589878..4590798 + 921 WP_045327152.1 alpha/beta hydrolase -
M5T14_RS21835 (M5T14_21835) 4590807..4591748 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
M5T14_RS21840 (M5T14_21840) 4591793..4592230 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
M5T14_RS21845 (M5T14_21845) 4592227..4593108 - 882 WP_003861949.1 virulence factor BrkB family protein -
M5T14_RS21850 (M5T14_21850) 4593102..4593701 - 600 WP_003861947.1 glucose-1-phosphatase -
M5T14_RS21855 (M5T14_21855) 4593820..4594620 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13697.77 Da        Isoelectric Point: 6.4882

>T256125 WP_045327153.1 NZ_CP103674:c4589434-4589063 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVSLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT256125 WP_015569912.1 NZ_CP103674:c4589679-4589437 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References