Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2812603..2813214 Replicon chromosome
Accession NZ_CP103674
Organism Enterobacter hormaechei strain 1074

Toxin (Protein)


Gene name hicA Uniprot ID D2TUP9
Locus tag M5T14_RS13400 Protein ID WP_012906750.1
Coordinates 2812603..2812782 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A6G3F240
Locus tag M5T14_RS13405 Protein ID WP_045339414.1
Coordinates 2812804..2813214 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T14_RS13380 (M5T14_13380) 2808469..2809344 + 876 WP_015570244.1 ATP-binding cassette domain-containing protein -
M5T14_RS13385 (M5T14_13385) 2809341..2810057 + 717 WP_017384431.1 ABC transporter ATP-binding protein -
M5T14_RS13390 (M5T14_13390) 2810223..2810693 + 471 WP_017384432.1 hypothetical protein -
M5T14_RS13395 (M5T14_13395) 2810699..2811625 - 927 WP_017384433.1 LysR substrate-binding domain-containing protein -
M5T14_RS13400 (M5T14_13400) 2812603..2812782 + 180 WP_012906750.1 type II toxin-antitoxin system HicA family toxin Toxin
M5T14_RS13405 (M5T14_13405) 2812804..2813214 + 411 WP_045339414.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M5T14_RS13410 (M5T14_13410) 2813248..2814003 + 756 WP_023299879.1 glycosyltransferase family 25 protein -
M5T14_RS13415 (M5T14_13415) 2814022..2814444 - 423 WP_023299878.1 tail fiber assembly protein -
M5T14_RS13420 (M5T14_13420) 2814446..2817007 - 2562 WP_259384929.1 phage tail protein -
M5T14_RS13425 (M5T14_13425) 2817010..2817561 - 552 WP_023299876.1 phage tail protein I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fliA 2809353..2862918 53565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6644.85 Da        Isoelectric Point: 10.9132

>T256122 WP_012906750.1 NZ_CP103674:2812603-2812782 [Enterobacter hormaechei]
MDSRNAIAMIEADGWYLVRVKGSHHQFKHPTKKGLVTVKHPQKDIPLPTLKSIKKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14890.79 Da        Isoelectric Point: 4.3170

>AT256122 WP_045339414.1 NZ_CP103674:2812804-2813214 [Enterobacter hormaechei]
MLYPVAIDKGDSSFGVRVPDIPGCFSGGDDYQDAIESVREAIEAHIELLVEDGESVPEATTVENWLSDPEYAGAVWALVD
VDITRLMGKAEKINVTLPSLLIRRIDQFVAAHPEYGSRSGFLSRVAADKVIGREKR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6XDK4

Antitoxin

Source ID Structure
AlphaFold DB A0A6G3F240

References