Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2271308..2272047 Replicon chromosome
Accession NZ_CP103674
Organism Enterobacter hormaechei strain 1074

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag M5T14_RS10765 Protein ID WP_003857133.1
Coordinates 2271308..2271793 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag M5T14_RS10770 Protein ID WP_003857131.1
Coordinates 2271781..2272047 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T14_RS10740 (M5T14_10740) 2266848..2267606 - 759 WP_023296628.1 trans-aconitate 2-methyltransferase -
M5T14_RS10745 (M5T14_10745) 2267691..2268275 - 585 WP_017382349.1 GDP-mannose pyrophosphatase nudK -
M5T14_RS10750 (M5T14_10750) 2268362..2269120 + 759 WP_047719552.1 DeoR/GlpR family DNA-binding transcription regulator -
M5T14_RS10755 (M5T14_10755) 2269225..2270517 + 1293 WP_259385434.1 glycosyl hydrolase family 28 protein -
M5T14_RS10760 (M5T14_10760) 2270517..2271131 + 615 WP_080346687.1 NUDIX hydrolase -
M5T14_RS10765 (M5T14_10765) 2271308..2271793 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
M5T14_RS10770 (M5T14_10770) 2271781..2272047 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
M5T14_RS10775 (M5T14_10775) 2272111..2273040 - 930 WP_259385435.1 LysR family transcriptional regulator -
M5T14_RS10780 (M5T14_10780) 2273170..2274558 + 1389 WP_259385436.1 MFS transporter -
M5T14_RS10785 (M5T14_10785) 2274580..2275575 - 996 WP_259385437.1 DUF2891 domain-containing protein -
M5T14_RS10790 (M5T14_10790) 2275585..2276571 - 987 WP_023296632.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2258792..2272047 13255


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T256117 WP_003857133.1 NZ_CP103674:c2271793-2271308 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT256117 WP_003857131.1 NZ_CP103674:c2272047-2271781 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References