Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1127535..1128155 Replicon chromosome
Accession NZ_CP103674
Organism Enterobacter hormaechei strain 1074

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag M5T14_RS05355 Protein ID WP_015571250.1
Coordinates 1127535..1127753 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag M5T14_RS05360 Protein ID WP_006809850.1
Coordinates 1127781..1128155 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T14_RS05325 (M5T14_05325) 1123547..1123807 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
M5T14_RS05330 (M5T14_05330) 1123810..1123950 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M5T14_RS05335 (M5T14_05335) 1123947..1124657 - 711 WP_032670463.1 GNAT family protein -
M5T14_RS05340 (M5T14_05340) 1124759..1126219 + 1461 WP_059294834.1 PLP-dependent aminotransferase family protein -
M5T14_RS05345 (M5T14_05345) 1126191..1126658 - 468 WP_017383209.1 YlaC family protein -
M5T14_RS05350 (M5T14_05350) 1126775..1127326 - 552 WP_017383210.1 maltose O-acetyltransferase -
M5T14_RS05355 (M5T14_05355) 1127535..1127753 - 219 WP_015571250.1 HHA domain-containing protein Toxin
M5T14_RS05360 (M5T14_05360) 1127781..1128155 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
M5T14_RS05365 (M5T14_05365) 1128666..1131812 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
M5T14_RS05370 (M5T14_05370) 1131835..1133028 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T256116 WP_015571250.1 NZ_CP103674:c1127753-1127535 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT256116 WP_006809850.1 NZ_CP103674:c1128155-1127781 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References