Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 641613..642189 Replicon chromosome
Accession NZ_CP103674
Organism Enterobacter hormaechei strain 1074

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag M5T14_RS03065 Protein ID WP_015572580.1
Coordinates 641613..641900 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag M5T14_RS03070 Protein ID WP_259385214.1
Coordinates 641887..642189 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T14_RS03040 (M5T14_03040) 636706..637425 + 720 WP_017383867.1 winged helix-turn-helix domain-containing protein -
M5T14_RS03045 (M5T14_03045) 637575..638045 + 471 WP_045333472.1 MarR family transcriptional regulator -
M5T14_RS03050 (M5T14_03050) 638042..639109 + 1068 WP_086524236.1 HlyD family secretion protein -
M5T14_RS03055 (M5T14_03055) 639099..640175 + 1077 WP_015572578.1 DUF2955 domain-containing protein -
M5T14_RS03060 (M5T14_03060) 640172..641443 - 1272 WP_015572579.1 DUF445 domain-containing protein -
M5T14_RS03065 (M5T14_03065) 641613..641900 + 288 WP_015572580.1 BrnT family toxin Toxin
M5T14_RS03070 (M5T14_03070) 641887..642189 + 303 WP_259385214.1 BrnA antitoxin family protein Antitoxin
M5T14_RS03075 (M5T14_03075) 642218..642856 - 639 WP_259385215.1 LysE family translocator -
M5T14_RS03080 (M5T14_03080) 642895..643647 - 753 WP_259385216.1 AraC family transcriptional regulator -
M5T14_RS03085 (M5T14_03085) 643801..645171 + 1371 WP_032647147.1 NAD-dependent succinate-semialdehyde dehydrogenase -
M5T14_RS03090 (M5T14_03090) 645353..645898 - 546 WP_006810254.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T256115 WP_015572580.1 NZ_CP103674:641613-641900 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11514.19 Da        Isoelectric Point: 10.4094

>AT256115 WP_259385214.1 NZ_CP103674:641887-642189 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAMRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References