Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4489438..4490033 Replicon chromosome
Accession NZ_CP103673
Organism Escherichia coli strain 4069

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag M4U10_RS21410 Protein ID WP_019842229.1
Coordinates 4489438..4489788 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag M4U10_RS21415 Protein ID WP_001223213.1
Coordinates 4489782..4490033 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4U10_RS21390 (4484768) 4484768..4485790 - 1023 WP_001550507.1 ABC transporter permease -
M4U10_RS21395 (4485804) 4485804..4487306 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
M4U10_RS21400 (4487438) 4487438..4488394 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M4U10_RS21405 (4488704) 4488704..4489234 + 531 WP_000055075.1 inorganic diphosphatase -
M4U10_RS21410 (4489438) 4489438..4489788 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
M4U10_RS21415 (4489782) 4489782..4490033 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M4U10_RS21420 (4490245) 4490245..4490586 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
M4U10_RS21425 (4490589) 4490589..4494368 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T256112 WP_019842229.1 NZ_CP103673:c4489788-4489438 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT256112 WP_001223213.1 NZ_CP103673:c4490033-4489782 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References