Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4477776..4478298 Replicon chromosome
Accession NZ_CP103673
Organism Escherichia coli strain 4069

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag M4U10_RS21350 Protein ID WP_001105433.1
Coordinates 4477776..4478066 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag M4U10_RS21355 Protein ID WP_000212715.1
Coordinates 4478056..4478298 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4U10_RS21335 (4472944) 4472944..4474599 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
M4U10_RS21340 (4474993) 4474993..4477131 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
M4U10_RS21345 (4477311) 4477311..4477775 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M4U10_RS21350 (4477776) 4477776..4478066 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4U10_RS21355 (4478056) 4478056..4478298 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M4U10_RS21360 (4478490) 4478490..4478876 - 387 WP_001232246.1 cytochrome b562 -
M4U10_RS21365 (4479059) 4479059..4480411 - 1353 WP_001162173.1 metalloprotease PmbA -
M4U10_RS21370 (4480505) 4480505..4481056 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
M4U10_RS21375 (4481206) 4481206..4482579 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T256111 WP_001105433.1 NZ_CP103673:c4478066-4477776 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT256111 WP_000212715.1 NZ_CP103673:c4478298-4478056 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References