Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3178542..3179353 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name TacT2 Uniprot ID G0JME4
Locus tag ACIFE_RS15580 Protein ID WP_014030534.1
Coordinates 3178542..3179063 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID G0JME5
Locus tag ACIFE_RS15585 Protein ID WP_014030535.1
Coordinates 3179060..3179353 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS15540 3174131..3174880 - 750 WP_014030525.1 ABC transporter ATP-binding protein -
ACIFE_RS15545 3174880..3175689 - 810 WP_014030526.1 ABC transporter permease -
ACIFE_RS15550 3175860..3176021 + 162 Protein_3105 type II toxin-antitoxin system prevent-host-death family antitoxin -
ACIFE_RS15555 3176204..3176437 + 234 WP_035192126.1 hypothetical protein -
ACIFE_RS15560 3176434..3176871 + 438 WP_014030529.1 type II toxin-antitoxin system VapC family toxin -
ACIFE_RS15565 3177165..3177449 - 285 WP_014030530.1 DUF1778 domain-containing protein -
ACIFE_RS15570 3177803..3178129 - 327 WP_014030532.1 type II toxin-antitoxin system PemK/MazF family toxin -
ACIFE_RS15575 3178116..3178346 - 231 WP_014030533.1 hypothetical protein -
ACIFE_RS15580 3178542..3179063 - 522 WP_014030534.1 GNAT family N-acetyltransferase Toxin
ACIFE_RS15585 3179060..3179353 - 294 WP_014030535.1 DUF1778 domain-containing protein Antitoxin
ACIFE_RS15590 3179411..3180553 - 1143 WP_014030536.1 dTDP-glucose 4,6-dehydratase -
ACIFE_RS15595 3180573..3181469 - 897 WP_014030537.1 dTDP-4-dehydrorhamnose reductase -
ACIFE_RS15600 3181466..3182014 - 549 WP_014030538.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
ACIFE_RS15605 3182011..3182895 - 885 WP_014030539.1 glucose-1-phosphate thymidylyltransferase RfbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-142)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 18741.62 Da        Isoelectric Point: 8.1299

>T25611 WP_014030534.1 NC_015942:c3179063-3178542 [Acidithiobacillus ferrivorans SS3]
VRLSAPEPITAQHELGFFTCGEESLDFWIRHRALKNQATGASRTFVVCERRRVLAYYALAASAIACANAAGRFRRNMPDP
IPVVILGRLAVDQACQGKGWGRALVQDAALRILQAADVIGIRGVIVQAASGSAKAFYEKMGFDASPLDPMTLLLTLEDLR
ASLLPDPAESNFQ

Download         Length: 522 bp

>T25611 NC_015942:c3179063-3178542 [Acidithiobacillus ferrivorans SS3]
GTGAGGCTATCTGCACCGGAACCGATCACCGCACAGCACGAACTTGGGTTCTTTACCTGTGGCGAGGAGAGTCTGGATTT
TTGGATCAGGCATCGGGCGTTAAAAAATCAGGCCACGGGCGCCTCCCGGACCTTCGTGGTTTGCGAACGGCGCCGAGTTT
TGGCCTATTATGCACTGGCTGCGAGTGCTATCGCATGTGCCAATGCGGCAGGACGATTCCGGCGTAATATGCCGGATCCC
ATTCCTGTCGTCATTCTCGGCCGTCTGGCGGTGGACCAAGCCTGTCAGGGTAAAGGCTGGGGACGGGCACTGGTACAGGA
TGCGGCACTACGCATTCTACAGGCTGCGGATGTCATCGGGATCCGGGGCGTCATCGTACAGGCCGCGTCCGGCTCTGCTA
AAGCCTTTTACGAAAAAATGGGTTTTGATGCCTCCCCGCTGGACCCCATGACCCTGTTGCTGACGCTGGAAGATTTACGC
GCGAGTTTGCTGCCTGATCCTGCGGAATCAAACTTTCAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10916.52 Da        Isoelectric Point: 9.3371

>AT25611 WP_014030535.1 NC_015942:c3179353-3179060 [Acidithiobacillus ferrivorans SS3]
MSAAPDISCKRDTLNIRIKPEERNLIDRAARARGKNRTDFILDAARMAAEEALFAPVILVSDAQVFADFLVRLDRPPQSN
PRLRKTMQAPAPWNADE

Download         Length: 294 bp

>AT25611 NC_015942:c3179353-3179060 [Acidithiobacillus ferrivorans SS3]
ATGTCCGCCGCACCCGATATTTCCTGTAAACGAGATACCCTGAATATCCGGATCAAACCCGAAGAGCGCAATCTCATTGA
CCGCGCGGCCAGGGCACGCGGCAAAAATCGCACGGATTTCATACTGGATGCAGCGCGCATGGCGGCAGAAGAAGCATTGT
TTGCCCCGGTGATCCTGGTCAGCGATGCACAAGTTTTTGCCGACTTCCTGGTGCGTTTGGACAGGCCACCGCAATCCAAC
CCACGTTTGCGGAAGACCATGCAGGCACCGGCTCCCTGGAATGCGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7XVW2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B9BYQ4

References