Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3988102..3988756 Replicon chromosome
Accession NZ_CP103673
Organism Escherichia coli strain 4069

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag M4U10_RS18920 Protein ID WP_000244777.1
Coordinates 3988102..3988509 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M4U10_RS18925 Protein ID WP_000354046.1
Coordinates 3988490..3988756 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4U10_RS18900 (3984059) 3984059..3985792 - 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -
M4U10_RS18905 (3985798) 3985798..3986508 - 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M4U10_RS18910 (3986533) 3986533..3987429 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M4U10_RS18915 (3987541) 3987541..3988062 + 522 WP_001055874.1 flavodoxin FldB -
M4U10_RS18920 (3988102) 3988102..3988509 - 408 WP_000244777.1 protein YgfX Toxin
M4U10_RS18925 (3988490) 3988490..3988756 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M4U10_RS18930 (3988999) 3988999..3989979 + 981 WP_000886083.1 tRNA-modifying protein YgfZ -
M4U10_RS18935 (3990175) 3990175..3990834 - 660 WP_000250274.1 hemolysin III family protein -
M4U10_RS18940 (3990998) 3990998..3991309 - 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
M4U10_RS18945 (3991354) 3991354..3992787 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
M4U10_RS18950 (3992844) 3992844..3993587 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T256109 WP_000244777.1 NZ_CP103673:c3988509-3988102 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT256109 WP_000354046.1 NZ_CP103673:c3988756-3988490 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References