Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2966716..2967296 Replicon chromosome
Accession NC_015942
Organism Acidithiobacillus ferrivorans SS3

Toxin (Protein)


Gene name mazF Uniprot ID G0JUD8
Locus tag ACIFE_RS14555 Protein ID WP_009569044.1
Coordinates 2966716..2967057 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0JUD9
Locus tag ACIFE_RS14560 Protein ID WP_014030346.1
Coordinates 2967057..2967296 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACIFE_RS14530 2961764..2962297 - 534 WP_014030340.1 hypothetical protein -
ACIFE_RS14535 2962294..2962806 - 513 WP_014030341.1 hypothetical protein -
ACIFE_RS14540 2962796..2963353 - 558 WP_014030342.1 hypothetical protein -
ACIFE_RS14545 2963353..2964603 - 1251 WP_014030343.1 hypothetical protein -
ACIFE_RS14550 2965621..2966643 - 1023 WP_049786911.1 hypothetical protein -
ACIFE_RS14555 2966716..2967057 - 342 WP_009569044.1 endoribonuclease MazF Toxin
ACIFE_RS14560 2967057..2967296 - 240 WP_014030346.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ACIFE_RS14565 2967379..2970438 - 3060 WP_014030347.1 conjugal transfer protein TraN -
ACIFE_RS14570 2970442..2971689 - 1248 WP_148260371.1 TraU family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-104)

Antitoxin

SpoVT-AbrB domain

(6-45)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12494.42 Da        Isoelectric Point: 9.1834

>T25610 WP_009569044.1 NC_015942:c2967057-2966716 [Acidithiobacillus ferrivorans SS3]
MRSSYIPEAGDIVWLQFDPQAGHEQKGHRPALVLTPASYNGKTGLMICCPMTTQTKGYPFEVQITGKSPGVALADQVKSM
DWKERQARFKGQATPQELDEARAKACVLIGRKM

Download         Length: 342 bp

>T25610 NC_015942:c2967057-2966716 [Acidithiobacillus ferrivorans SS3]
ATGCGCAGCTCCTATATCCCGGAAGCCGGGGATATTGTTTGGTTGCAGTTTGATCCACAGGCTGGCCACGAACAGAAGGG
CCATAGGCCAGCTCTTGTACTGACTCCGGCGAGTTACAACGGTAAAACGGGGCTTATGATTTGCTGTCCCATGACGACGC
AGACCAAGGGATACCCATTCGAGGTGCAGATAACGGGCAAAAGCCCTGGTGTGGCACTCGCAGATCAGGTGAAGAGTATG
GACTGGAAAGAACGTCAAGCCCGCTTCAAAGGCCAGGCTACACCACAAGAATTGGATGAGGCAAGGGCTAAGGCATGTGT
CTTGATTGGACGAAAGATGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8523.89 Da        Isoelectric Point: 4.7318

>AT25610 WP_014030346.1 NC_015942:c2967296-2967057 [Acidithiobacillus ferrivorans SS3]
MRVIVKKWGNSAAVRMPAAVMDAAKLHLDEAVDVREEGGRIIIEPLWSGFNLDEMVAAITPENVHGAVDFGPAVGKELL

Download         Length: 240 bp

>AT25610 NC_015942:c2967296-2967057 [Acidithiobacillus ferrivorans SS3]
ATGCGAGTAATTGTGAAGAAATGGGGAAACAGTGCAGCCGTGCGTATGCCCGCCGCCGTGATGGATGCAGCCAAATTGCA
CCTGGACGAAGCCGTTGATGTGCGGGAAGAAGGTGGGCGTATCATTATCGAGCCGCTTTGGTCAGGTTTTAACCTGGACG
AAATGGTGGCGGCCATTACGCCCGAGAATGTGCATGGGGCGGTTGATTTCGGGCCTGCGGTGGGCAAGGAACTGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060UKH8

Antitoxin

Source ID Structure
AlphaFold DB A0A060UKU3

References