Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1663488..1664193 Replicon chromosome
Accession NZ_CP103673
Organism Escherichia coli strain 4069

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M4U10_RS07805 Protein ID WP_000539521.1
Coordinates 1663807..1664193 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M4U10_RS07800 Protein ID WP_001280945.1
Coordinates 1663488..1663817 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4U10_RS07785 (1658645) 1658645..1659556 + 912 Protein_1515 glutathione ABC transporter permease GsiD -
M4U10_RS07790 (1659734) 1659734..1662082 + 2349 WP_001550886.1 EAL domain-containing protein -
M4U10_RS07795 (1662090) 1662090..1663418 + 1329 WP_001550887.1 GGDEF domain-containing protein -
M4U10_RS07800 (1663488) 1663488..1663817 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M4U10_RS07805 (1663807) 1663807..1664193 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M4U10_RS07810 (1664419) 1664419..1665744 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M4U10_RS07815 (1665957) 1665957..1666340 + 384 WP_000497137.1 biofilm formation regulator BssR -
M4U10_RS07820 (1666451) 1666451..1667566 + 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
M4U10_RS07825 (1667563) 1667563..1668189 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T256097 WP_000539521.1 NZ_CP103673:c1664193-1663807 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT256097 WP_001280945.1 NZ_CP103673:c1663817-1663488 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References