Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1258235..1258853 Replicon chromosome
Accession NZ_CP103673
Organism Escherichia coli strain 4069

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M4U10_RS06015 Protein ID WP_001291435.1
Coordinates 1258235..1258453 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M4U10_RS06020 Protein ID WP_000344800.1
Coordinates 1258479..1258853 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M4U10_RS05980 (1253524) 1253524..1254096 + 573 WP_000779831.1 YbaY family lipoprotein -
M4U10_RS05985 (1254127) 1254127..1254438 - 312 WP_000409911.1 MGMT family protein -
M4U10_RS05995 (1254817) 1254817..1255170 + 354 WP_001550741.1 DUF1428 family protein -
M4U10_RS06000 (1255212) 1255212..1256762 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M4U10_RS06005 (1256926) 1256926..1257396 - 471 WP_000136192.1 YlaC family protein -
M4U10_RS06010 (1257512) 1257512..1258063 - 552 WP_000102564.1 maltose O-acetyltransferase -
M4U10_RS06015 (1258235) 1258235..1258453 - 219 WP_001291435.1 HHA domain-containing protein Toxin
M4U10_RS06020 (1258479) 1258479..1258853 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M4U10_RS06025 (1259399) 1259399..1262548 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
M4U10_RS06030 (1262571) 1262571..1263764 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T256096 WP_001291435.1 NZ_CP103673:c1258453-1258235 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT256096 WP_000344800.1 NZ_CP103673:c1258853-1258479 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References