Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4635258..4635853 Replicon chromosome
Accession NZ_CP103672
Organism Escherichia coli O25b:H4-ST131 strain 4433

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag M5S92_RS23185 Protein ID WP_000239579.1
Coordinates 4635258..4635608 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag M5S92_RS23190 Protein ID WP_001223208.1
Coordinates 4635602..4635853 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S92_RS23165 (4630704) 4630704..4631726 - 1023 WP_001296689.1 ABC transporter permease -
M5S92_RS23170 (4631740) 4631740..4633242 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
M5S92_RS23175 (4633382) 4633382..4634338 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5S92_RS23180 (4634648) 4634648..4635178 + 531 WP_000055075.1 inorganic diphosphatase -
M5S92_RS23185 (4635258) 4635258..4635608 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
M5S92_RS23190 (4635602) 4635602..4635853 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5S92_RS23195 (4636065) 4636065..4636406 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5S92_RS23200 (4636409) 4636409..4640188 - 3780 WP_135103450.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T256088 WP_000239579.1 NZ_CP103672:c4635608-4635258 [Escherichia coli O25b:H4-ST131]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT256088 WP_001223208.1 NZ_CP103672:c4635853-4635602 [Escherichia coli O25b:H4-ST131]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References