Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4665074..4665999 Replicon chromosome
Accession NZ_CP103657
Organism Escherichia coli strain 3150

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag M5R25_RS22610 Protein ID WP_014640052.1
Coordinates 4665074..4665460 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag M5R25_RS22615 Protein ID WP_024174200.1
Coordinates 4665490..4665999 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R25_RS22575 (4660639) 4660639..4660839 - 201 WP_021527487.1 YdaS family helix-turn-helix protein -
M5R25_RS22580 (4660930) 4660930..4661604 + 675 WP_021530636.1 LexA family transcriptional regulator -
M5R25_RS22585 (4662272) 4662272..4662634 + 363 WP_000135680.1 protein YfdP -
M5R25_RS22590 (4662700) 4662700..4663524 + 825 WP_023908886.1 DUF2303 family protein -
M5R25_RS22595 (4663713) 4663713..4664495 + 783 WP_023908887.1 hypothetical protein -
M5R25_RS22600 (4664532) 4664532..4664813 + 282 WP_001093916.1 pyocin activator PrtN family protein -
M5R25_RS22605 (4664861) 4664861..4665034 - 174 WP_023908888.1 hypothetical protein -
M5R25_RS22610 (4665074) 4665074..4665460 - 387 WP_014640052.1 hypothetical protein Toxin
M5R25_RS22615 (4665490) 4665490..4665999 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
M5R25_RS22620 (4666316) 4666316..4666420 - 105 Protein_4433 tRNA-dihydrouridine synthase -
M5R25_RS22625 (4666782) 4666782..4667786 - 1005 WP_022646425.1 DUF2713 family protein -
M5R25_RS22630 (4668104) 4668104..4668619 + 516 WP_000416263.1 zinc uptake transcriptional repressor Zur -
M5R25_RS22635 (4668661) 4668661..4668870 - 210 WP_001296638.1 CsbD family protein -
M5R25_RS22640 (4668986) 4668986..4670311 - 1326 WP_001361471.1 MATE family efflux transporter DinF -
M5R25_RS22645 (4670384) 4670384..4670992 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4627165..4670992 43827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T256060 WP_014640052.1 NZ_CP103657:c4665460-4665074 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT256060 WP_024174200.1 NZ_CP103657:c4665999-4665490 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References