Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4438174..4438769 Replicon chromosome
Accession NZ_CP103657
Organism Escherichia coli strain 3150

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag M5R25_RS21435 Protein ID WP_000239581.1
Coordinates 4438174..4438524 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag M5R25_RS21440 Protein ID WP_001223213.1
Coordinates 4438518..4438769 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R25_RS21415 (4433628) 4433628..4434650 - 1023 WP_001298067.1 ABC transporter permease -
M5R25_RS21420 (4434664) 4434664..4436166 - 1503 WP_022646474.1 sugar ABC transporter ATP-binding protein -
M5R25_RS21425 (4436299) 4436299..4437255 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5R25_RS21430 (4437565) 4437565..4438095 + 531 WP_000055075.1 inorganic diphosphatase -
M5R25_RS21435 (4438174) 4438174..4438524 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
M5R25_RS21440 (4438518) 4438518..4438769 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
M5R25_RS21445 (4438981) 4438981..4439322 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5R25_RS21450 (4439325) 4439325..4443104 - 3780 WP_022646473.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T256058 WP_000239581.1 NZ_CP103657:c4438524-4438174 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT256058 WP_001223213.1 NZ_CP103657:c4438769-4438518 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References